How does a β-hairpin fold/unfold?: Competition between topology and heterogeneity in a solvable model

被引：17

作者：

Guo, CL

Levine, H

Kessler, DA

机构：

[1] Univ Calif San Diego, Dept Phys, La Jolla, CA 92093 USA

[2] Bar Ilan Univ, Dept Phys, IL-52900 Ramat Gan, Israel

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2000年 / 97卷 / 20期

关键词：

D O I：

10.1073/pnas.190103297

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We study the competition between topological effects and sequence inhomogeneities in determining the thermodynamics and the un/folding kinetics of a beta-hairpin. Our work utilizes a new exactly solvable model that allows for arbitrary configurations of native contacts. In general, the competition between heterogeneity and topology results in a crossover of the dominant transition state. Interestingly. near this crossover, the single reaction coordinate picture can be seriously misleading. Our results also suggest that inferring the folding pathway from unfolding simulations is not always justified.

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页码：10775 / 10779

页数：5

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