Hair cell fate decisions in cochlear development and regeneration

被引:75
作者
Cotanche, Douglas A. [1 ,2 ,3 ,4 ]
Kaiser, Christina L. [1 ,2 ]
机构
[1] Boston Univ, Sch Med, Dept Otolaryngol, Boston, MA 02118 USA
[2] Boston Univ, Sch Med, Lab Cellular & Mol Hearing Res, Boston, MA 02118 USA
[3] Harvard Univ, Sch Med, Dept Otol & Laryngol, Boston, MA 02114 USA
[4] Harvard MIT, Div Hlth Sci & Technol, Cambridge, MA 02139 USA
关键词
Cochlea; Hair cell; Supporting cell; Genetic regulation; Notch pathway; Development; Regeneration; MOUSE INNER-EAR; AVIAN AUDITORY EPITHELIUM; LIGHT-MICROSCOPIC EVIDENCE; CHICK COCHLEA; MAMMALIAN COCHLEA; ACOUSTIC TRAUMA; DIFFERENTIAL EXPRESSION; BASILAR PAPILLA; DIRECT TRANSDIFFERENTIATION; RETINOBLASTOMA PROTEIN;
D O I
10.1016/j.heares.2010.04.012
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
The discovery of avian cochlear hair cell regeneration in the late 1980s and the concurrent development of new techniques in molecular and developmental biology generated a renewed interest in understanding the genetic mechanisms that regulate hair cell development in the embryonic avian and mammalian cochlea and regeneration in the mature avian cochlea. Research from many labs has demonstrated that the development of the inner ear utilizes a complex series of genetic signals and pathways to generate the endorgans, specify cell identities, and establish innervation patterns found in the inner ear. Recent studies have shown that the Notch signaling pathway, the Atoh1/Hes signaling cascade, the stem cell marker Sox2, and some of the unconventional myosin motor proteins are utilized to regulate distinct steps in inner ear development. While many of the individual genes involved in these pathways have been identified from studies of mutant and knockout mouse cochleae, the interplay of all these signals into a single systemic program that directs this process needs to be explored. We need to know not only what genes are involved, but understand how their gene products interact with one another in a structural and temporal framework to guide hair cell and supporting cell differentiation and maturation. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:18 / 25
页数:8
相关论文
共 85 条
[41]   Cellular commitment and differentiation in the organ of Corti [J].
Kelley, Matthew W. .
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2007, 51 (6-7) :571-583
[42]   Hair cell development: Commitment through differentiation [J].
Kelley, Matthew W. .
BRAIN RESEARCH, 2006, 1091 :172-185
[43]   The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear [J].
Kiernan, AE ;
Cordes, R ;
Kopan, R ;
Gossler, A ;
Gridley, T .
DEVELOPMENT, 2005, 132 (19) :4353-4362
[44]   Sox2 is required for sensory organ development in the mammalian inner ear [J].
Kiernan, AE ;
Pelling, AL ;
Leung, KKH ;
Tang, ASP ;
Bell, DM ;
Tease, C ;
Lovell-Badge, R ;
Steel, KP ;
Cheah, KSE .
NATURE, 2005, 434 (7036) :1031-1035
[45]   The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear [J].
Kiernan, Amy E. ;
Xu, Jingxia ;
Gridley, Thomas .
PLOS GENETICS, 2006, 2 (01) :27-38
[46]   Notch signalling pathway mediates hair cell development in mammalian cochlea [J].
Lanford, PJ ;
Lan, Y ;
Jiang, RL ;
Lindsell, C ;
Weinmaster, G ;
Gridley, T ;
Kelley, MW .
NATURE GENETICS, 1999, 21 (03) :289-292
[47]   Expression of Math1 and HES5 in the cochleae of wildtype and Jag2 mutant mice [J].
Lanford, RJ ;
Shailam, R ;
Norton, CR ;
Gridley, T ;
Kelley, MW .
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY, 2000, 1 (02) :161-171
[48]   DETECTION OF BETA-ACTIN MESSENGER-RNA BY RT-PCR IN NORMAL AND REGENERATING CHICKEN COCHLEAE [J].
LEE, KH ;
COTANCHE, DA .
HEARING RESEARCH, 1995, 87 (1-2) :9-15
[49]   Potential role of bFGF and retinoic acid in the regeneration of chicken cochlear hair cells [J].
Lee, KH ;
Cotanche, DA .
HEARING RESEARCH, 1996, 94 (1-2) :1-13
[50]   A morphogenetic wave of p27Kip1 transcription directs cell cycle exit during organ of Corti development [J].
Lee, Yun-Shain ;
Liu, Feng ;
Segil, Neil .
DEVELOPMENT, 2006, 133 (15) :2817-2826