TGFβ signalling: a complex web in cancer progression

被引：915

作者：

Ikushima, Hiroaki ^{[1
]}

Miyazono, Kohei ^{[1
]}

机构：

[1] Univ Tokyo, Dept Mol Pathol, Grad Sch Med, Tokyo 1130033, Japan

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 06期

关键词：

GROWTH-FACTOR-BETA; EPITHELIAL-MESENCHYMAL TRANSITIONS; RECEPTOR KINASE INHIBITOR; TRANSCRIPTION FACTOR DEC1; HORMONE-RELATED PROTEIN; PROMOTES TUMOR-GROWTH; NON-HODGKINS-LYMPHOMA; BREAST-CANCER; STEM-CELLS; TRANSFORMING GROWTH-FACTOR-BETA-1;

D O I：

10.1038/nrc2853

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-beta (TGF beta) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour-stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGF beta signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGF beta signalling and contribute to the regulation of TGF beta-induced cell responses, in this Review we discuss how they maintain the balance of TGF beta signalling and how their collapse leads to tumour progression.

引用

页码：415 / 424

页数：10

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