Synthesis and medical applications of oligosaccharides

被引：605

作者：

Seeberger, Peter H. ^{[1
]}

Werz, Daniel B. ^{[1
]}

机构：

[1] ETH, Swiss Fed Inst Technol, Organ Chem Lab, CH-8093 Zurich, Switzerland

来源：

NATURE | 2007年 / 446卷 / 7139期

关键词：

D O I：

10.1038/nature05819

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Our understanding of the different glycoconjugates present on cells, proteins and entire organisms is lagging far behind advances in genomics and proteomics. Carbohydrate sequencing and the synthesis of defined oligosaccharides are two key technologies that have contributed to progress in glycomics research. Synthetic tools and high-throughput experiments such as carbohydrate arrays are beginning to affect biological research. These techniques are now being applied to the development of carbohydrate-based diagnostics, vaccines and therapeutics.

引用

页码：1046 / 1051

页数：6

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