The TAK1-TRAF6 signalling pathway

被引：230

作者：

Landstrom, Marene ^{[1
]}

机构：

[1] Uppsala Univ, Dept Genet & Pathol, Rudbeck Lab, SE-75124 Uppsala, Sweden

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2010年 / 42卷 / 05期

基金：

英国医学研究理事会;

关键词：

Inflammation; Kinase activation; Transforming growth factor-beta; Ubiquitination; I-KAPPA-B; TGF-BETA; TAK1-BINDING PROTEIN-1; TAK1; ACTIVATION; TAB1; TRAF6; TRANSDUCTION; MAPKKK; FAMILY;

D O I：

10.1016/j.biocel.2009.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cellular responses to pathogens, growth factors, cytokines, extra- or intra-cellular stress, is a prerequisite for the cell to adapt to novel and potentially dangerous situations. If the changes in the extra- or intra-cellular milieu causes DNA-damage or revoke a signalling pathway utilized during morphogenesis, the epithelial cells might be forced to undergo programmed cell death (apoptosis) in the benefit for the whole organism or transform to a mesenchymal cell type (epithelial to mesenchymal transition; EMT), in respond to a specific stimuli. An overview is presented over the current knowledge for the key components in signal transduction in homeostasis, inflammation and cancer. A handful of transcription factors are crucial for the determination of the specific cellular responses, where the transforming growth factor-beta (TGF-beta) is an important factor as discussed in this review. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：585 / 589

页数：5

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