Frozen objects: Small airways, big breaths, and asthma

被引：68

作者：

Fredberg, JJ ^{[1
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2000年 / 106卷 / 04期

关键词：

smooth muscle; myosin; inflammation; maturation; hyperresponsiveness; respiration;

D O I：

10.1067/mai.2000.109429

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Airway hyperresponsiveness is one of the cardinal features of asthma but remains largely unexplained. The new concept of perturbed myosin binding within airway smooth muscle sheds light on the question of why airway narrowing is limited in the healthy lung and not in the asthmatic lung and points to unanticipated mechanisms through which lung development and allergic status may be major modulators of airway hyperresponsiveness.

引用

页码：615 / 624

页数：10

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