Radioactive ion beams for biomedical research and nuclear medical application

被引：28

作者：

Beyer, GJ ^{[1
]}

机构：

[1] Univ Hosp Geneva, Div Nucl Med, CH-1211 Geneva, Switzerland

来源：

HYPERFINE INTERACTIONS | 2000年 / 129卷 / 1-4期

关键词：

radio-lanthanides; CITRATE; EDTMP; DTPA; yttrium; cancer; radionuclide therapy; biokinetic; monoclonal antibodies; peptides; bioconjugates; dosimetry; PET; spallation; isotope production;

D O I：

10.1023/A:1012670018533

中图分类号：

O64 [物理化学（理论化学）、化学物理学]; O56 [分子物理学、原子物理学];

学科分类号：

070203 ; 070304 ; 081704 ; 1406 ;

摘要：

In this article a review is given on the research strategies, on experimental work and application of ISOLDE produced radionuclides used in the field of biomedicine over a period of more than 2 decades. Special attention will be directed to the radio-lanthanides for several reasons: firstly, the radio-lanthanides are three-valent metallic radionuclides which show any radiation properties we wish (single photon emission suitable for SPECT, positron emission suitable for PET, beta (-)- and Auger electron emission suitable for therapy). Even the alpha decay mode (suitable for therapy in selected cases) is available in the lanthanide group. Secondly, the 15 lanthanides can be seen chemically as one single element for labelling of tracer molecules, providing the unique possibility to study systematically relationships between physico-chemical molecule parameter and a biological response without changes in the basic tracer molecule. Very recent developments in bioconjugation chemistry call for three-valent metallic radionuclides for all kinds of nuclear medical application: diagnosis, in vivo dosimetry and radionuclide therapy where the rare-earth elements will play an important role in future.

引用

页码：529 / 553

页数：25

共 63 条

[41] CLINICAL EVALUATION OF TUMOR SCANNING WITH YB-169-CITRATE [J].

HISADA, K ;

SUZUKI, Y ;

HIRAKI, T ;

SANO, H ;

SUZAKI, K .

RADIOLOGY, 1975, 116 (02) :389-393

[42]

HISADA K, 1973, J NUCL MED, V14, P615

[43] THE PREPARATION OF DTPA-COUPLED ANTIBODIES RADIOLABELED WITH METALLIC RADIONUCLIDES - AN IMPROVED METHOD [J].

HNATOWICH, DJ ;

CHILDS, RL ;

LANTEIGNE, D ;

NAJAFI, A .

JOURNAL OF IMMUNOLOGICAL METHODS, 1983, 65 (1-2) :147-157

[44]

KANO J, 1974, IRIGAKU SOSHO, V96, P49

[45]

KOVALIK A, 1990, E690477 JINR

[46] SOMATOSTATIN RECEPTOR SCINTIGRAPHY WITH [IN-111-DTPA-D-PHE(1)]- AND [I-123-TYR(3)]-OCTREOTIDE - THE ROTTERDAM EXPERIENCE WITH MORE THAN 1000 PATIENTS [J].

KRENNING, EP ;

KWEKKEBOOM, DJ ;

BAKKER, WH ;

BREEMAN, WAP ;

KOOIJ, PPM ;

OEI, HY ;

VANHAGEN, M ;

POSTEMA, PTE ;

DEJONG, M ;

REUBI, JC ;

VISSER, TJ ;

REIJS, AEM ;

HOFLAND, LJ ;

KOPER, JW ;

LAMBERTS, SWJ .

EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1993, 20 (08) :716-731

[47]

KRENNING EP, 1995, NUCL MED ANN, V199, P1

[48]

Kuhne A, 1976, Radiobiol Radiother (Berl), V17, P111

[49]

KUTZNER J, 1981, NUKLEARMED, V20, P229

[50]

Lawrence JH, 1939, P SOC EXP BIOL MED, V40, P694

← 1 2 3 4 5 6 7 →