Influence of formulation variables on the morphology of biodegradable microparticles prepared by spray drying

被引：27

作者：

Clarke, N ^{[1
]}

O'Connor, K ^{[1
]}

Ramtoola, Z ^{[1
]}

机构：

[1] Univ Dublin Trinity Coll, Elan Res Inst, Elan Pharmaceut Technol, Dublin 2, Ireland

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1998年 / 24卷 / 02期

关键词：

D O I：

10.3109/03639049809085602

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of microparticles of the biodegradable poly-DL-lactide (PLA) and polylactide-co-glycolide (PLGA) polymers using spray-drying technology was studied. Formulation parameters investigated include polymer type, polymer molecular weight, polymer concentration, and viscosity. Microparticles were characterized using electron microscopy, particle size analysis, and gel permeation chromatography. Kinematic viscosity was determined for each of the sprayed polymer solutions. Polymer molecular weight and polymer concentration were found to be important parameters when preparing PLA and PLGA microparticles using spray-drying technology.

引用

页码：169 / 174

页数：6

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