Synthesis of spiro diphosphines and their application in asymmetric hydrogenation of ketones

被引：273

作者：

Xie, JH

Wang, LX

Fu, Y

Zhu, SF

Fan, BM

Duan, HF

Zhou, QL ^{[1
]}

机构：

[1] Nankai Univ, Stat Key Lab, Tianjin 300071, Peoples R China

[2] Nankai Univ, Inst Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2003年 / 125卷 / 15期

关键词：

D O I：

10.1021/ja029907i

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthesis of chiral diphosphine ligands containing a spiro scaffold was described. The ruthenium complexes of these spiro ligands were found to have extremely high activities (S/C up to 100000) and enantioselectivities (ee up to 99.5%) in the asymmetric hydrogenation of aromatic, heteroaromatic, and α,β-unsaturated ketones. Copyright © 2003 American Chemical Society.

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页码：4404 / 4405

页数：2

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