Coordinated expression of ig-like inhibitory MHC class I receptors and acquisition of cytotoxic function in human CD8+ T cells

被引:88
作者
Anfossi, N
Doisne, JM
Peyrat, MA
Ugolini, S
Bonnaud, O
Bossy, D
Pitard, V
Merville, P
Moreau, JF
Delfraissy, JF
Dechanet-Merville, J
Bonneville, M [1 ]
Venet, A
Vivier, E
机构
[1] INSERM, Unite 463, Inst Biol, F-44035 Nantes 01, France
[2] Univ Bordeaux 3, CIRID, CNRS, UMR 5164, Bordeaux, France
[3] Fac Med Paris Sud, INSERM, Equipe 0109, F-94276 Le Kremlin Bicetre, France
[4] Beckman Coulter Immunotech, Marseille, France
[5] Univ Mediterranee, CNRS, INSERM, Ctr Immunol Marseille Luminy, Marseille, France
关键词
D O I
10.4049/jimmunol.173.12.7223
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
MHC class I-specific inhibitory receptors are expressed by a subset of memory-phenotype CD8(+) T cells. Similar to NK cells, MHC class I-specific inhibitory receptors might subserve on T cells an important negative control that participates to the prevention of autologous damage. We analyzed here human CD8(+) T cells that express the Ig-like MHC class I-specific inhibitory receptors: killer cell Ig-like receptor (KIR) and CD85j. The cell surface expression of Ig-like inhibitory MHC class I receptors was found to correlate with an advanced stage of CD8(+) T cell maturation as evidenced by the reduced proliferative potential of KIR+ and CD85j(+). T cells associated with their high intracytoplasmic perforin content. This concomitant regulation might represent a safety mechanism to control potentially harmful cytolytic CD8(+) T cells, by raising their activation threshold. Yet, KIR+ and CD85j(+) T cells present distinct features. KIR(+)CD8(+) T cells are poor IFN-gamma producers upon TCR engagement. In addition, KIR are barely detectable at the surface of virus-specific T cells during the course of CMV or HIV-1 infection. By contrast, CD85j(+)CD8(+) T cells produce IFN-gamma upon TCR triggering, and represent a large fraction of virus-specific T cells. Thus, the cell surface expression of Ig-like inhibitory MHC class I receptors is associated with T cell engagement into various stages of the cytolytic differentiation pathway, and the cell surface expression of CD85j or KIR witnesses to the history of qualitatively and/or quantitatively distinct T cell activation events.
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页码:7223 / 7229
页数:7
相关论文
共 43 条
[1]   Expansion and function of CD8+ T cells, expressing Ly49 inhibitory receptors specific for MHC class I molecules [J].
Anfossi, N ;
Robbins, SH ;
Ugolini, S ;
Georgel, P ;
Hoebe, K ;
Bouneaud, C ;
Ronet, C ;
Kaser, A ;
DiCioccio, CB ;
Tomasello, E ;
Blumberg, RS ;
Beutler, B ;
Reiner, SL ;
Alexopoulou, L ;
Lantz, O ;
Raulet, DH ;
Brossay, L ;
Vivier, E .
JOURNAL OF IMMUNOLOGY, 2004, 173 (06) :3773-3782
[2]   Biology of T memory type 1 cells [J].
Anfossi, N ;
Pascal, V ;
Vivier, E ;
Ugolini, S .
IMMUNOLOGICAL REVIEWS, 2001, 181 :269-278
[3]   Mouse CD1-specific NK1 T cells: Development, specificity, and function [J].
Bendelac, A ;
Rivera, MN ;
Park, SH ;
Roark, JH .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :535-562
[4]   LIR-1 expression on lymphocytes, and cytomegalovirus disease in lung-transplant recipients [J].
Berg, L ;
Riise, GC ;
Cosman, D ;
Bergström, T ;
Olofsson, S ;
Kärre, W ;
Carbone, E .
LANCET, 2003, 361 (9363) :1099-1101
[5]   Skewed maturation of memory HIV-specific CD8 T lymphocytes [J].
Champagne, P ;
Ogg, GS ;
King, AS ;
Knabenhans, C ;
Ellefsen, K ;
Nobile, M ;
Appay, V ;
Rizzardi, GP ;
Fleury, S ;
Lipp, M ;
Förster, R ;
Rowland-Jones, S ;
Sékaly, RP ;
McMichael, AJ ;
Pantaleo, G .
NATURE, 2001, 410 (6824) :106-111
[6]   Molecular mechanism of the activation-induced cell death inhibition mediated by a p70 receptor in Jurkat T cells [J].
Chwae, YJ ;
Chang, MJ ;
Park, SM ;
Yoon, H ;
Park, HJ ;
Kim, SJ ;
Kim, J .
JOURNAL OF IMMUNOLOGY, 2002, 169 (07) :3726-3735
[7]   A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells [J].
Colonna, M ;
Navarro, F ;
Bellon, T ;
Llano, M ;
Garcia, P ;
Samaridis, J ;
Angman, L ;
Cella, M ;
LopezBotet, M .
JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (11) :1809-1818
[8]   The biology of human natural killer-cell subsets [J].
Cooper, MA ;
Fehniger, TA ;
Caligiuri, MA .
TRENDS IN IMMUNOLOGY, 2001, 22 (11) :633-640
[9]   A novel immunoglobulin superfamily receptor for cellular and viral MHC class I molecules [J].
Cosman, D ;
Fanger, N ;
Borges, L ;
Kubin, M ;
Chin, W ;
Peterson, L ;
Hsu, ML .
IMMUNITY, 1997, 7 (02) :273-282
[10]   Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles [J].
DAndrea, A ;
Chang, C ;
Phillips, JH ;
Lanier, LL .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :789-794