Role of respiratory syncytial virus in acute otitis media: Implications for vaccine development

被引：33

作者：

Patel, Janak A. ^{[1
]}

Nguyen, Dang T. ^{[1
]}

Revai, Krystal ^{[1
]}

Chonmaitree, Tasnee ^{[1
]}

机构：

[1] Univ Texas, Div Pediat Infect Dis & Immunol, Dept Pediat, Sealy Ctr Vaccine Dev,Med Branch, Galveston, TX 77555 USA

来源：

VACCINE | 2007年 / 25卷 / 09期

关键词：

otitis media; respiratory syncytial virus; vaccine;

D O I：

10.1016/j.vaccine.2006.10.045

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We summarize herein the results of various virologic studies of acute otitis media (AOM) conducted at our site over a 10-year period. Among 566 children with AOM, respiratory syncytial virus (RSV) was the most common virus identified in either middle ear fluid or nasal wash it was found in 16% of all children and 38% of virus-positive children. Seventy-one percent of the children with RSV were I year of age or older, which was significantly older than all other viruses combined (P = 0.045). RSV infection was associated with the common bacterial pathogens causing AOM. Past efforts to develop vaccines for RSV have emphasized prevention of lower respiratory tract infection in infants, which is a more serious problem but less common than AOM. Our results Suggest that RSV vaccines that work only against infection in older children may have value in preventing AOM, the most common pediatric disease. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1683 / 1689

页数：7

共 33 条

[11] Twenty years of outpatient respiratory syncytial virus infection: A framework for vaccine efficacy trials [J].

Fisher, RG ;

Gruber, WC ;

Edwards, KM ;

Reed, GW ;

Tollefson, SJ ;

Thompson, JM ;

Wright, PF .

PEDIATRICS, 1997, 99 (02) :E71-E75

[12]

FRIEDLANDER SK, 1998, APPL OCCUP ENV HYG, V13, P1

[13] RISK OF PRIMARY INFECTION AND REINFECTION WITH RESPIRATORY SYNCYTIAL VIRUS [J].

GLEZEN, WP ;

TABER, LH ;

FRANK, AL ;

KASEL, JA .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1986, 140 (06) :543-546

[14] National impact of universal childhood immunization with pneumococcal conjugate vaccine on outpatient medical care visits in the United States [J].

Grijalva, Carlos G. ;

Poehling, Katherine A. ;

Nuorti, J. Pekka ;

Zhu, Yuwei ;

Martin, Stacey W. ;

Edwards, Kathryn M. ;

Griffin, Marie R. .

PEDIATRICS, 2006, 118 (03) :865-873

[15] Differences in antibiotic prescribing patterns for children younger than five years in the three major outpatient settings [J].

Halasa, NB ;

Griffin, MR ;

Zhu, YW ;

Edwards, KM .

JOURNAL OF PEDIATRICS, 2004, 144 (02) :200-205

[16]

Hall C. B., 2004, TXB PEDIAT INFECT DI, P2315

[17] Importance of respiratory viruses in acute otitis media [J].

Heikkinen, T ;

Chonmaitree, T .

CLINICAL MICROBIOLOGY REVIEWS, 2003, 16 (02) :230-+

[18] Prevalence of various respiratory viruses in the middle ear during acute otitis media [J].

Heikkinen, T ;

Thint, M ;

Chonmaitree, T .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (04) :260-264

[19] INFLUENZA VACCINATION IN THE PREVENTION OF ACUTE OTITIS-MEDIA IN CHILDREN [J].

HEIKKINEN, T ;

RUUSKANEN, O ;

WARIS, M ;

ZIEGLER, T ;

AROLA, M ;

HALONEN, P .

AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1991, 145 (04) :445-448

[20] A LONGITUDINAL-STUDY OF RESPIRATORY VIRUSES AND BACTERIA IN THE ETIOLOGY OF ACUTE OTITIS-MEDIA WITH EFFUSION [J].

HENDERSON, FW ;

COLLIER, AM ;

SANYAL, MA ;

WATKINS, JM ;

FAIRCLOUGH, DL ;

CLYDE, WA ;

DENNY, FW .

NEW ENGLAND JOURNAL OF MEDICINE, 1982, 306 (23) :1377-1383

← 1 2 3 4 →