Dehydrative reduction:: A highly diastereoselective synthesis of syn-bisaryi(or heteroaryl) dihydrobenzoxathiins and benzodioxane

被引：27

作者：

Kim, S ^{[1
]}

Wu, JY ^{[1
]}

Chen, HY ^{[1
]}

DiNinno, F ^{[1
]}

机构：

[1] Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 05期

关键词：

D O I：

10.1021/ol0274763

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] TFA/Et3SIH-mediated cyclization of thioketones 5 derived from the reaction of functionalized thiophenols (catechols) with bromo ketones gave syn 2,3-bisaryl(or heteroaryl) dihydrobenzoxathiins and benzodioxane 1 with total diastereoselectivity (>99:1), in excellent yields.

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页码：685 / 688

页数：4

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