Oxazolomycins: Natural product lead structures for novel antibacterials by click fragment conjugation

被引：21

作者：

Bagwell, Claire L. ^{[1
]}

Moloney, Mark G. ^{[1
]}

Yaqoob, Muhammad ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

Antibacterials; Natural products; Click conjugation; DIASTEREOCONTROLLED SYNTHESIS; TETRAMIC ACIDS; DRUGS; CHEMISTRY; DISCOVERY; COMPOUND; PYROGLUTAMATES; BIOSYNTHESIS; CURROMYCIN; INHIBITOR;

D O I：

10.1016/j.bmcl.2010.02.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Conjugation of amide and lactam subunits by a 'Click' type approach provides access to structural mimics of the oxazolomycin series of natural products, some of which exhibit antibacterial activity. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：2090 / 2094

页数：5

共 62 条

[31] Stereocontrolled spirocyclic bislactams derived from pyroglutamic acid [J].

Hill, TJ ;

Kocis, P ;

Moloney, MG .

TETRAHEDRON LETTERS, 2006, 47 (09) :1461-1463

[32] Tetramic Acids as Scaffolds: Synthesis, Tautomeric and Antibacterial Behaviour [J].

Jeong, Yong-Chul ;

Moloney, Mark G. .

SYNLETT, 2009, (15) :2487-2491

[33] Compound library development guided by protein structure similarity clustering and natural product structure [J].

Koch, MA ;

Wittenberg, LO ;

Basu, S ;

Jeyaraj, DA ;

Gourzoulidou, E ;

Reinecke, K ;

Odermatt, A ;

Waldmann, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (48) :16721-16726

[34] Protein structure similarity clustering and natural product structure as guiding principles in drug discovery [J].

Koch, MA ;

Waldmann, H .

DRUG DISCOVERY TODAY, 2005, 10 (07) :471-483

[35]

Kotra LP, 2000, CHEM IND-LONDON, P341

[36]

MCBAIN AJ, 2003, ENV SCI BIOTECHNOL, V2, P141

[37] Equilibration in bicyclic pyroglutamates by ring opening-reclosure [J].

Moloney, Mark G. ;

Yaqoob, Muhammad .

TETRAHEDRON LETTERS, 2008, 49 (43) :6202-6204

[38]

Moloney Mark G, 2004, Curr Drug Discov Technol, V1, P181, DOI 10.2174/1570163043334974

[39] High-Throughput Screen for Novel Antimicrobials using a Whole Animal Infection Model [J].

Moy, Terence I. ;

Conery, Annie L. ;

Larkins-Ford, Jonah ;

Wu, Gang ;

Mazitschek, Ralph ;

Casadei, Gabriele ;

Lewis, Kim ;

Carpenter, Anne E. ;

Ausubel, Frederick M. .

ACS CHEMICAL BIOLOGY, 2009, 4 (07) :527-533

[40] Identification of novel antimicrobials using a live-animal infection model [J].

Moy, Terence I. ;

Ball, Anthony R. ;

Anklesaria, Zafia ;

Casadei, Gabriele ;

Lewis, Kim ;

Ausubel, Frederick M. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (27) :10414-10419

← 1 2 3 4 5 6 7 →