Microwave assisted combinatorial chemistry synthesis of substituted pyridines

被引：115

作者：

Cotterill, IC

Usyatinsky, AY

Arnold, JM

Clark, DS

Dordick, JS

Michels, PC

Khmelnitsky, YL

机构：

[1] EnzyMed Inc, Iowa City, IA 52242 USA

[2] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

[3] Univ Iowa, Dept Chem & Biochem Engn, Iowa City, IA 52242 USA

[4] Univ Iowa, Ctr Biocatalysis & Bioproc, Iowa City, IA 52242 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(97)10796-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new highly efficient MICROCOS technology (Microwave-assisted Combinatorial Synthesis) for generating combinatorial libraries is described. The technology is applied to the high throughput, automated, one-step, parallel synthesis of diverse substituted pyridines using the Hantzsch synthesis. The advantages of microwave-assisted chemistry for combinatorial synthesis include a broad range of available chemistries, simple reaction setup and product recovery readily amenable to automation, extremely short reaction times, and high product yields. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：1117 / 1120

页数：4

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