Cyclodextrin-based pharmaceutics: Past, present and future

被引：1631

作者：

Davis, ME ^{[1
]}

Brewster, ME

机构：

[1] CALTECH, Pasadena, CA 91125 USA

[2] Johnson & Johnson Pharmaceut Res & Dev, B-2340 Beerse, Belgium

来源：

NATURE REVIEWS DRUG DISCOVERY | 2004年 / 3卷 / 12期

关键词：

D O I：

10.1038/nrd1576

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cyclodextrins are cyclic oligomers of glucose that can form water-soluble inclusion complexes with small molecules and portions of large compounds. These biocompatible, cyclic oligosaccharides do not elicit immune responses and have low toxicities in animals and humans. Cyclodextrins are used in pharmaceutical applications for numerous purposes, including improving the bioavailability of drugs. Current cyclodextrin-based therapeutics are described and possible future applications discussed. Cyclodextrin-containing polymers are reviewed and their use in drug delivery presented. Of specific interest is the use of cyclodextrin-containing polymers to provide unique capabilities for the delivery of nucleic acids.

引用

页码：1023 / 1035

页数：13

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