Preliminary magnetic resonance study of the macromolecular proton fraction in white matter: a potential marker of myelin?

被引：31

作者：

Davies, GR ^{[1
]}

Ramani, A ^{[1
]}

Dalton, CM ^{[1
]}

Tozer, DJ ^{[1
]}

Wheeler-Kingshott, CAM ^{[1
]}

Barker, GJ ^{[1
]}

Thompson, AJ ^{[1
]}

Miller, DH ^{[1
]}

Tofts, PS ^{[1
]}

机构：

[1] UCL, Inst Neurol, NMR Res Unit, London WC1N 3BG, England

来源：

MULTIPLE SCLEROSIS JOURNAL | 2003年 / 9卷 / 03期

关键词：

grey matter; magnetization transfer imaging; MRI; multiple sclerosis; myelin; normal-appearing white matter;

D O I：

10.1191/1352458503ms911oa

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report on a new quantitative magnetization transfer (MT) technique that allows for the in vivo estimation of the macromolecular pro ton fraction (f) and the bound pool T2 relaxation time (T2b), whilst permitting whole brain coverage. In this pilot study, five subjects with multiple sclerosis (MS) and five healthy controls were studied. Both f and T2b were significantly different between MS lesions and normal control white matter (WM). Relationships between f and T1 relaxation time [Spearman's rank correlation coefficient (r(s)) = -0.97, P<0.001] and f and the magnetization transfer ratio (MTR; r(s)=0.80, P<0.001) were observed. Compared with MTR, f and T2b have the potential advantage of relative independence from MT acquisition protocol while offering more pathologically specific information. In particular, f may provide a more direct indication of myelin content in WM.

引用

页码：246 / 249

页数：4

共 17 条

[1]

Berry I, 1999, J MAGN RESON IMAGING, V9, P441, DOI 10.1002/(SICI)1522-2586(199903)9:3<441::AID-JMRI12>3.0.CO

[2]

2-R

[3]

EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING [J].

DOUSSET, V ;

GROSSMAN, RI ;

RAMER, KN ;

SCHNALL, MD ;

YOUNG, LH ;

GONZALEZSCARANO, F ;

LAVI, E ;

COHEN, JA .

RADIOLOGY, 1992, 182 (02) :483-491

[4]

A MAGNETIZATION-TRANSFER IMAGING STUDY OF NORMAL-APPEARING WHITE-MATTER IN MULTIPLE-SCLEROSIS [J].

FILIPPI, M ;

CAMPI, A ;

DOUSSET, V ;

BARATTI, C ;

MARTINELLI, V ;

CANAL, N ;

SCOTTI, G ;

COMI, G .

NEUROLOGY, 1995, 45 (03) :478-482

[5]

QUANTITATIVE INTERPRETATION OF MAGNETIZATION-TRANSFER [J].

HENKELMAN, RM ;

HUANG, XM ;

XIANG, QS ;

STANISZ, GJ ;

SWANSON, SD ;

BRONSKILL, MJ .

MAGNETIC RESONANCE IN MEDICINE, 1993, 29 (06) :759-766

[6]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

[7]

IN-VIVO VISUALIZATION OF MYELIN WATER IN BRAIN BY MAGNETIC-RESONANCE [J].

MACKAY, A ;

WHITTALL, K ;

ADLER, J ;

LI, D ;

PATY, D ;

GRAEB, D .

MAGNETIC RESONANCE IN MEDICINE, 1994, 31 (06) :673-677

[8]

Accurate multislice gradient echo T1 measurement in the presence of non-ideal RF pulse shape and RF field nonuniformity [J].

Parker, GJM ;

Barker, GJ ;

Tofts, PS .

MAGNETIC RESONANCE IN MEDICINE, 2001, 45 (05) :838-845

[9]

NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[10]

Precise estimate of fundamental in-vivo MT parameters in human brain in clinically feasible times [J].

Ramani, A ;

Dalton, C ;

Miller, DH ;

Tofts, PS ;

Barker, GJ .

MAGNETIC RESONANCE IMAGING, 2002, 20 (10) :721-731

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