Simple synthesis of mono- and difluoroalanines

被引：27

作者：

Gerus, II

Kolomeitsev, AA

Kolycheva, MI

Kukhar, VP

机构：

[1] Natl Acad Sci Ukraine, Inst Bioorgan & Petrochem, UA-253660 Kiev 94, Ukraine

[2] Natl Acad Sci Ukraine, Inst Organ Chem, UA-253660 Kiev, Ukraine

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2000年 / 105卷 / 01期

关键词：

fluorinated amino acids; difluoromethylation; fluoromethylation; tris(diethylamino)-N-methylphosphazene;

D O I：

10.1016/S0022-1139(00)00258-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Highly basic tris(diethylamino)-N-methylphosphazene was used for mono- and difluoromethylation of diethyl N-acetylaminomalonate by CH2BrF or CHClF2 in dichloromethane at -40 degrees C. Acidic hydrolysis of fluoromethylated products afforded fluoro- and difluoroalanine, respectively. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：31 / 33

页数：3

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