Inside sensors detecting outside pathogens

被引：4

作者：

De Gregorio, E ^{[1
]}

Rappuoli, R ^{[1
]}

机构：

[1] Chiron Corp, Vaccines, I-53100 Siena, Italy

来源：

NATURE IMMUNOLOGY | 2004年 / 5卷 / 11期

关键词：

D O I：

10.1038/ni1104-1099

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How innate immunity discriminates between noninvasive bacterial pathogens and commensals is unclear. The finding that epithelial cells recognize peptidoglycan fragments of Helicobacter pylori delivered by the type IV secretion system suggests an intriguing solution.

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收藏

页码：1099 / 1100

页数：2

相关论文

共 12 条

[1] Mammalian Toll-like receptors [J].

Akira, S .

CURRENT OPINION IN IMMUNOLOGY, 2003, 15 (01) :5-11

[2] Helicobacter pylori enter and survive within multivesicular vacuoles of epithelial cells [J].

Amieva, MR ;

Salama, NR ;

Tompkins, LS ;

Falkow, S .

CELLULAR MICROBIOLOGY, 2002, 4 (10) :677-690

[3] The versatile bacterial type IV secretion systems [J].

Cascales, E ;

Christie, PJ .

NATURE REVIEWS MICROBIOLOGY, 2003, 1 (02) :137-149

[4]

Chamaillard M, 2003, NAT IMMUNOL, V4, P702, DOI 10.1038/ni945

[5] Tyrosine-phosphorylated bacterial proteins: Trojan horses for the host cell - Commentary [J].

Covacci, A ;

Rappuoli, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 191 (04) :587-592

[6] Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection [J].

Girardin, SE ;

Boneca, IG ;

Viala, J ;

Chamaillard, M ;

Labigne, A ;

Thomas, G ;

Philpott, DJ ;

Sansonetti, PJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (11) :8869-8872

[7] Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan [J].

Girardin, SE ;

Boneca, IG ;

Carneiro, LAM ;

Antignac, A ;

Jéhanno, M ;

Viala, J ;

Tedin, K ;

Taha, MK ;

Labigne, A ;

Zähringer, U ;

Coyle, AJ ;

Bertin, J ;

Sansonetti, PJ ;

Philpott, DJ .

SCIENCE, 2003, 300 (5625) :1584-1587

[8] Response of human pulmonary epithelial cells to lipopolysaccharide involves Toll-like receptor 4 (TLR4)-dependent signaling pathways - Evidence for an intracellular compartmentalization of TLR4 [J].

Guillot, L ;

Medjane, S ;

Le-Barillec, K ;

Balloy, V ;

Danel, C ;

Chignard, M ;

Si-Tahar, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (04) :2712-2718

[9] Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells [J].

Hornef, MW ;

Normark, BH ;

Vandewalle, A ;

Normark, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (08) :1225-1235

[10] Cytolysin-mediated translocation (CMT): A functional equivalent of type III secretion in Gram-positive bacteria [J].

Madden, JC ;

Ruiz, N ;

Caparon, M .

CELL, 2001, 104 (01) :143-152