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Insights into insulin resistance and type 2 diabetes from knockout mouse models

被引：192
作者：
Kadowaki, T [1 ]
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Metab Dis, Tokyo 1138655, Japan
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2000年 / 106卷 / 04期
关键词：
D O I：
10.1172/JCI10830
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
[No abstract available]
引用
收藏
页码：459 / 465
页数：7
相关论文
共 49 条
  • [1] Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1
    Abe, H
    Yamada, N
    Kamata, K
    Kuwaki, T
    Shimada, M
    Osuga, J
    Shionoiri, F
    Yahagi, N
    Kadowaki, T
    Tamemoto, H
    Ishibashi, S
    Yazaki, Y
    Makuuchi, M
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (08) : 1784 - 1788
  • [2] Early neonatal death in mice homozygous for a null allele of the insulin receptor gene
    Accili, D
    Drago, J
    Lee, EJ
    Johnson, MD
    Cool, MH
    Salvatore, P
    Asico, LD
    Jose, PA
    Taylor, SI
    Westphal, H
    [J]. NATURE GENETICS, 1996, 12 (01) : 106 - 109
  • [3] ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE
    ARAKI, E
    LIPES, MA
    PATTI, ME
    BRUNING, JC
    HAAG, B
    JOHNSON, RS
    KAHN, CR
    [J]. NATURE, 1994, 372 (6502) : 186 - 190
  • [4] PPARγ, the ultimate thrifty gene
    Auwerx, J
    [J]. DIABETOLOGIA, 1999, 42 (09) : 1033 - 1049
  • [5] PPARγ is required for placental, cardiac, and adipose tissue development
    Barak, Y
    Nelson, MC
    Ong, ES
    Jones, YZ
    Ruiz-Lozano, P
    Chien, KR
    Koder, A
    Evans, RM
    [J]. MOLECULAR CELL, 1999, 4 (04) : 585 - 595
  • [6] Bruning JC, 1997, MOL CELL BIOL, V17, P1513
  • [7] A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    Bruning, JC
    Michael, MD
    Winnay, JN
    Hayashi, T
    Horsch, D
    Accili, D
    Goodyear, LJ
    Kahn, CR
    [J]. MOLECULAR CELL, 1998, 2 (05) : 559 - 569
  • [8] Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    Bruning, JC
    Winnay, J
    BonnerWeir, S
    Taylor, SI
    Accili, D
    Kahn, CR
    [J]. CELL, 1997, 88 (04) : 561 - 572
  • [9] Interactions between insulin resistance and insulin secretion in the development of glucose intolerance
    Cavaghan, MK
    Ehrmann, DA
    Polonsky, KS
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (03) : 329 - 333
  • [10] Lack of insulin receptors affects the formation of white adipose tissue in mice. A morphometric and ultrastructural analysis
    Cinti, S
    Eberbach, S
    Castellucci, M
    Accili, D
    [J]. DIABETOLOGIA, 1998, 41 (02) : 171 - 177
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