Detection of resistance genes and susceptibility patterns in Bacteroides and Parabacteroides strains

被引：102

作者：

Boente, Renata F. ^{[1
]}

Ferreira, Livia Q. ^{[1
]}

Falcao, Lais S. ^{[1
]}

Miranda, Karla R. ^{[1
]}

Guimaraes, Priscilla L. S. ^{[1
]}

Santos-Filho, Joaquim ^{[1
]}

Vieira, Jessica M. B. D. ^{[1
]}

Barroso, David E. ^{[2
]}

Emond, Jean-Philippe ^{[3
]}

Ferreira, Eliane O. ^{[1
]}

Paula, Geraldo R. ^{[4
]}

Domingues, Regina M. C. P. ^{[1
]}

机构：

[1] Inst Microbiol Prof Paulo de Goes UFRJ, Dept Med Microbiol, Lab Biol Anaerobios, Ctr Ciencias Saude, BR-21941902 Rio De Janeiro, Brazil

[2] Fiocruz MS, Inst Oswaldo Cruz, Lab Sistemat Bioquim, BR-21040900 Rio De Janeiro, Brazil

[3] Ctr Hosp Intercommunal, F-94195 Paris, France

[4] Fac Farm UFF, Dept Tecnol Farmaceut, Niteroi, RJ, Brazil

来源：

ANAEROBE | 2010年 / 16卷 / 03期

关键词：

Bacteroides; Parabacteroides; Antimicrobial resistance; Resistance genes; CONJUGATIVE TRANSPOSON; NIM GENES; CFXA GENE; FRAGILIS; DISTASONIS; SPP; CFIA;

D O I：

10.1016/j.anaerobe.2010.02.003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 [微生物学];

摘要：

Susceptibility to five antimicrobials was determined for Bacteroides spp. (n = 52) and Parabacteroides distasonis (n = 8). All isolates were susceptible to metronidazole. The resistance rates to ampicillin, cefoxitin, tetracycline and clindamycin were 98%, 9.6%, 65.3% and 19.2% of the Bacteroides strains, respectively. The genes cepA, cfiA, cfxA, tetQ, ermF and nim were found in 69.2%, 17.3% 9.6%, 50%, 7.7% and 3.8% for these strains respectively. All P. distasonis strains were resistant to ampicilin. Cefoxitin, tetracycline and clindamycin resistance rates were 75%, 87.5% and 50%, respectively. The ermF and nim genes were absent and 37.5%, 12.5%, 12.5% and 87.5% of this strains possessed cepA, cfiA, cfxA and tetQ genes, respectively. Ten cfiA gene positive strains of Bacteroides and Parabacteroides were submitted to E-test with imipenem and amoxicillin clavulanate. The resistance rate to imipenem was 4.1% and 8.3% to amoxicillin clavulanate. This feature is for the first time described in Brazil. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：190 / 194

页数：5

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