Isolation and characterization of [3H]fucose-labeled glycoproteins from the serum of normal rats and rats bearing Zajdela hepatoma

被引：6

作者：

Ivanov, D ^{[1
]}

Antonova, M ^{[1
]}

Stoilov, J ^{[1
]}

Zacharieva, S ^{[1
]}

Gavazova, E ^{[1
]}

Ivanov, S ^{[1
]}

机构：

[1] Bulgarian Acad Sci, Inst Expt Pathol & Parasitol, BU-1113 Sofia, Bulgaria

来源：

CANCER LETTERS | 1998年 / 125卷 / 1-2期

关键词：

serum; glycoproteins; hepatoma; fucosylation; preparative isoelectrofocusing;

D O I：

10.1016/S0304-3835(97)00524-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Specific [H-3]fucose-labeled glycoproteins were found in the serum of rats bearing Zajdela hepatoma, which possess different isoelectric points in comparison with serum glycoproteins from normal rats. The electrophoretic profile of the serum glycoproteins is significantly altered. There is approximately a 2.5 times increase of [H-3]fucose incorporation into serum glycoproteins from rats with an ascitic form of hepatoma, compared with normal rats and to animals bearing a solid form of the tumor (which have a considerably greater survival). Serum fucoproteins identical for the two forms of hepatoma were isolated, as well as glycoproteins strongly specific for each of the forms. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：227 / 231

页数：5

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