Molecular control of cytoskeletal mechanics by hemodynamic forces

被引：43

作者：

Helmke, BP ^{[1
]}

机构：

[1] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22903 USA

[2] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00040.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The endothelium at the interface between blood and tissue acts as a primary transducer of local hemodynamic forces into signals that maintain physiological function or initiate pathological processes in vessel walls. Rapid intracellular spatial gradients of structural dynamics and signaling molecule activity suggest that mechanical cues at the molecular level guide cellular mechanotransduction and adaptation to shear stress profiles.

引用

页码：43 / 53

页数：11

共 88 条

[1] Measurement of local viscoelasticity and forces in living cells by magnetic tweezers [J].

Bausch, AR ;

Möller, W ;

Sackmann, E .

BIOPHYSICAL JOURNAL, 1999, 76 (01) :573-579

[2] A new in vitro model to evaluate differential responses of endothelial cells to simulated arterial shear stress waveforms [J].

Blackman, BR ;

García-Cardeña, G ;

Gimbrone, MA .

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME, 2002, 124 (04) :397-407

[3] Drebrin is a novel connexin-43 binding partner that links gap junctions to the submembrane cytoskeleton [J].

Butkevich, E ;

Hülsmann, S ;

Wenzel, D ;

Shirao, T ;

Duden, R ;

Majoul, I .

CURRENT BIOLOGY, 2004, 14 (08) :650-658

[4] Integrating the actin and vimentin cytoskeletons: Adhesion-dependent formation of fimbrin-vimentin complexes in macrophages [J].

Correia, I ;

Chu, D ;

Chou, YH ;

Goldman, RD ;

Matsudaira, P .

JOURNAL OF CELL BIOLOGY, 1999, 146 (04) :831-842

[5] Regulation of tension-induced mechanotranscriptional signals by the microtubule network in fibroblasts [J].

D'Addario, M ;

Arora, PD ;

Ellen, RP ;

McCulloch, CAG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (52) :53090-53097

[6] FLOW-MEDIATED ENDOTHELIAL MECHANOTRANSDUCTION [J].

DAVIES, PF .

PHYSIOLOGICAL REVIEWS, 1995, 75 (03) :519-560

[7] QUANTITATIVE STUDIES OF ENDOTHELIAL-CELL ADHESION - DIRECTIONAL REMODELING OF FOCAL ADHESION SITES IN RESPONSE TO FLOW FORCES [J].

DAVIES, PF ;

ROBOTEWSKYJ, A ;

GRIEM, ML .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 93 (05) :2031-2038

[8] Spatial relationships in early signaling events of flow-mediated endothelial mechanotransduction [J].

Davies, PF ;

Barbee, KA ;

Volin, MV ;

Robotewskyj, A ;

Chen, J ;

Joseph, L ;

Griem, ML ;

Wernick, MN ;

Jacobs, E ;

Polacek, DC ;

DePaola, N ;

Barakat, AI .

ANNUAL REVIEW OF PHYSIOLOGY, 1997, 59 :527-549

[9] Shear stress regulates occludin content and phosphorylation [J].

Demaio, L ;

Chang, YS ;

Gardner, TW ;

Tarbell, JM ;

Antonetti, DA .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2001, 281 (01) :H105-H113

[10] Spatial and temporal regulation of gap junction connexin43 in vascular endothelial cells exposed to controlled disturbed flows in vitro [J].

DePaola, N ;

Davies, PF ;

Pritchard, WF ;

Florez, L ;

Harbeck, N ;

Polacek, DC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (06) :3154-3159

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