Molecular control of cytoskeletal mechanics by hemodynamic forces

被引：43

作者：

Helmke, BP ^{[1
]}

机构：

[1] Univ Virginia, Dept Biomed Engn, Charlottesville, VA 22903 USA

[2] Univ Virginia, Cardiovasc Res Ctr, Charlottesville, VA USA

来源：

PHYSIOLOGY | 2005年 / 20卷

关键词：

D O I：

10.1152/physiol.00040.2004

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The endothelium at the interface between blood and tissue acts as a primary transducer of local hemodynamic forces into signals that maintain physiological function or initiate pathological processes in vessel walls. Rapid intracellular spatial gradients of structural dynamics and signaling molecule activity suggest that mechanical cues at the molecular level guide cellular mechanotransduction and adaptation to shear stress profiles.

引用

页码：43 / 53

页数：11

共 88 条

[51] Comparison of filamin A-induced cross-linking and Arp2/3 complex-mediated branching on the mechanics of actin filaments [J].

Nakamura, F ;

Osborn, E ;

Janmey, PA ;

Stossel, TP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (11) :9148-9154

[52] Transient and steady-state effects of shear stress on endothelial cell adherens junctions [J].

Noria, S ;

Cowan, DB ;

Gotlieb, AI ;

Langille, BL .

CIRCULATION RESEARCH, 1999, 85 (06) :504-514

[53] Assembly and reorientation of stress fibers drives morphological changes to endothelial cells exposed to shear stress [J].

Noria, S ;

Xu, F ;

McCue, S ;

Jones, M ;

Gotlieb, AI ;

Langille, BL .

AMERICAN JOURNAL OF PATHOLOGY, 2004, 164 (04) :1211-1223

[54] The small GTPase RalA targets filamin to induce filopodia [J].

Ohta, Y ;

Suzuki, N ;

Nakamura, S ;

Hartwig, JH ;

Stossel, TP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (05) :2122-2128

[55] HEMODYNAMIC SHEAR-STRESS ACTIVATES A K+ CURRENT IN VASCULAR ENDOTHELIAL-CELLS [J].

OLESEN, SP ;

CLAPHAM, DE ;

DAVIES, PF .

NATURE, 1988, 331 (6152) :168-170

[56] Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction: is it a mechanoresponsive molecule? [J].

Osawa, M ;

Masuda, M ;

Kusano, K ;

Fujiwara, K .

JOURNAL OF CELL BIOLOGY, 2002, 158 (04) :773-785

[57] Localized stabilization of microtubules by integrin- and FAK-facilitated Rho signaling [J].

Palazzo, AF ;

Eng, CH ;

Schlaepfer, DD ;

Marcantonio, EE ;

Gundersen, GG .

SCIENCE, 2004, 303 (5659) :836-839

[58] CLIP-170 highlights growing microtubule ends in vivo [J].

Perez, F ;

Diamantopoulos, GS ;

Stalder, R ;

Kreis, TE .

CELL, 1999, 96 (04) :517-527

[59] Mechanisms of disease - Atherosclerosis - An inflammatory disease [J].

Ross, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (02) :115-126

[60] Theoretical estimates of mechanical properties of the endothelial cell cytoskeleton [J].

Satcher, RL ;

Dewey, CF .

BIOPHYSICAL JOURNAL, 1996, 71 (01) :109-118

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