Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs

被引：572

作者：

Matera, A. Gregory ^{[1
]}

Terns, Rebecca M.

Terns, Michael P.

机构：

[1] Case Western Reserve Univ, Dept Genet, Cleveland, OH 44106 USA

[2] Univ Georgia, Dept Biochem, Athens, GA 30602 USA

[3] Univ Georgia, Dept Mol Biol & Genet, Athens, GA 30602 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 03期

关键词：

D O I：

10.1038/nrm2124

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function. The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for understanding the biogenesis of other ncRNPs.

引用

页码：209 / 220

页数：12

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