The outcome of percutaneous coronary intervention in patients with in-stent restenosis who failed intracoronary radiation therapy

被引:16
作者
Ajani, AE
Waksman, R
Cheneau, E
Cha, DH
McGlynn, S
Castagna, M
Chan, RC
Satler, LF
Kent, KM
Pichard, AD
Pinnow, E
Lindsay, J
机构
[1] Washington Hosp Ctr, Div Cardiol, Washington, DC 20010 USA
[2] Washington Hosp Ctr, Washington Canc Inst, Washington, DC 20010 USA
关键词
D O I
10.1016/S0735-1097(02)02859-0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVES This study reports the outcome of patients who failed intracoronary radiation therapy (IRT) for the treatment of in-stent restenosis (ISR). BACKGROUND Intracoronary radiation therapy has demonstrated a reduction in the recurrence rate of restenosis for patients with ISR. However, 10% to 30% of these patients require repeat intervention to the irradiated site. METHODS Of 961 patients who were assigned to gamma or beta radiation for the treatment of diffuse ISR, we evaluated the outcome of 282 (29%) consecutive patients who failed IRT and compared them with the 679 (71%) patients who had successful IRT. For patients who failed radiation, the mean time to the first target vessel revascularization (TVR) was 173 127 days after the index procedure and the total duration of follow-up was 494 +/- 304 days. RESULTS Patients who failed IRT were younger (60 +/- 10 vs. 63 +/- 11 years, p = 0.002) and had a higher incidence of restenting (51% vs. 41%, p = 0.003). The majority (55%) of the restenotic lesions after IRT failure were focal (less than or equal to10 mm), with a mean lesion length of 11.9 +/- 1.9 mm. Of the 257 patients who had subsequent TVR after failed IRT, 68 (26%) underwent coronary artery bypass grafting and 189 (74%) underwent percutaneous coronary intervention using balloon in 61%, restenting in 26%, atheroablation in 11%, and the cutting balloon in 2% of cases. At six months, 6% of patients died, 1% had Q-wave MI, 17% had repeat TVR, and the overall rate of major adverse cardiac events was 21%. CONCLUSIONS The predominant angiographic pattern of lesions in patients who failed IRT is focal restenosis, with these lesions responding well to conventional revascularization methods. U Am Coll Cardiol 2003;41:551-6) (C) 2003 by the American College of Cardiology Foundation.
引用
收藏
页码:551 / 556
页数:6
相关论文
共 20 条
  • [1] Cutting balloon angioplasty for the treatment of in-stent restenosis: A matched comparison with rotational atherectomy, additional stent implantation and balloon angioplasty
    Adamian, M
    Colombo, A
    Briguori, C
    Nishida, T
    Marsico, F
    Di Mario, C
    Albiero, R
    Moussa, I
    Moses, JW
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 38 (03) : 672 - 679
  • [2] Serial intravascular ultrasound of intracoronary γ-radiation assessment of the efficacy therapy for preventing recurrence in very long, diffuse, in-stent restenosis lesions
    Ahmed, JM
    Mintz, GS
    Waksman, R
    Mehran, R
    Leiboff, B
    Pichard, AD
    Satler, LF
    Kent, KM
    Weissman, NJ
    [J]. CIRCULATION, 2001, 104 (08) : 856 - 859
  • [3] Device selection in the treatment of in-stent restenosis with and without radiation (from the gamma radiation trials)
    Ajani, AE
    Waksman, R
    Zimarino, M
    Kim, HS
    Pichard, AD
    Satlar, LF
    Kent, KM
    White, RL
    Pinnow, E
    Mehran, R
    Lansky, A
    Lindsay, J
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (02) : 137 - 144
  • [4] Bauters C, 1998, CIRCULATION, V97, P318
  • [5] Casterella P J, 1999, Cardiol Rev, V7, P219, DOI 10.1097/00045415-199907000-00014
  • [6] Cha Dong-Hun, 2002, J Invasive Cardiol, V14, P432
  • [7] Reference chart derived from post-stent-implantation intravascular ultrasound predictors of 6-month expected restenosis on quantitative coronary angiography
    de Feyter, PJ
    Kay, P
    Disco, C
    Serruys, PW
    [J]. CIRCULATION, 1999, 100 (17) : 1777 - 1783
  • [8] Edge stenosis and geographical miss following intracoronary gamma radiation therapy for in-stent restenosis
    Kim, HS
    Waksman, R
    Cottin, Y
    Kollum, M
    Bhargava, B
    Mehran, R
    Chan, RC
    Mintz, GS
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2001, 37 (04) : 1026 - 1030
  • [9] Lansky AJ, 2000, CIRCULATION, V102, P669
  • [10] Localized intracoronary gamma-radiation therapy to inhibit the recurrence of restenosis after stenting.
    Leon, MB
    Teirstein, PS
    Moses, JW
    Tripuraneni, P
    Lansky, AJ
    Jani, S
    Wong, SC
    Fish, D
    Ellis, S
    Holmes, DR
    Kerieakes, D
    Kuntz, RE
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (04) : 250 - 256