Neuraminidase is important for the initiation of influenza virus infection in human airway epithelium

被引:458
作者
Matrosovich, MN
Matrosovich, TY
Gray, T
Roberts, NA
Klenk, HD
机构
[1] Univ Marburg, Inst Virol, D-35037 Marburg, Germany
[2] MP Chumakov Inst Poliomyelitis & Viral Encephalit, Moscow, Russia
[3] NIEHS, Mol Carcinogenesis Lab, Res Triangle Pk, NC 27709 USA
[4] Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, England
关键词
D O I
10.1128/JVI.78.22.12665-12667.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Influenza virus neuraminidase (NA) plays an essential role in release and spread of progeny virions, following the intracellular viral replication cycle. To test whether NA could also facilitate virus entry into cell, we infected cultures of human airway epithelium with human and avian influenza viruses in the presence of the NA inhibitor oseltamivir carboxylate. Twenty- to 500-fold less cells became infected in drug-treated versus nontreated cultures (P < 0.0001) 7 h after virus application, indicating that the drug suppressed the initiation of infection. These data demonstrate that viral NA plays a role early in infection, and they provide further rationale for the prophylactic use of NA inhibitors.
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页码:12665 / 12667
页数:3
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