Dietary habits and growth and recurrence of colorectal adenomas: Results from a three-year endoscopic follow-up study

被引:22
作者
Almendingen, K [1 ]
Hofstad, B
Vatn, MH
机构
[1] Univ Hosp Oslo, Rikshosp, Dept Med, Oslo, Norway
[2] Ullevaal Univ Hosp, Dept Med, Oslo, Norway
来源
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL | 2004年 / 49卷 / 02期
关键词
D O I
10.1207/s15327914nc4902_3
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Diet has been associated with sporadic colorectal cancer (CRC) risk. The relationship to the growth rate of adenomas is largely unknown. Previous analyses of our cohort of polyp cases have shown 1) indicators of a healthy diet were inversely associated with adenoma occurrence, 2) diet was related to the fecal profile, 3) obesity was positively associated with adenoma growth, 4) familial predisposition of CRC was positively associated with adenoma growth, and 5) intervention with calcium and antioxidants was not associated with adenoma growth. The present aim was to study the effects of diet on growth and recurrence of adenomas. Data were collected from a 3-yr polyp growth and intervention study. Polyps larger than 9 mm were removed, whereas the remainder and newly discovered polyps smaller than 10 mm were left in situ for 3 yr Diet was assessed by a 5-day dietary record by weighing (DR) and food-frequency questionnaire (FFQ). Weak inverse associations were found only between adenoma growth and fruits and berries (adjusted odds ratio, aOR = 0.3; 95% CI = 0.1-0.9) and carbohydrates (aOR = 0.1; 95% CI = 0.1-0.6; both only DR data) and between adenoma recurrence and vegetables (crude odds ratio, cOR = 0.4; 95% CI = 0.1-0.9; only FFQ data). Taken together the present and previous findings from this cohort may indicate an early role for dietary factors in CRC development.
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页码:131 / 138
页数:8
相关论文
共 46 条
[11]   Calcium and fibre supplementation in prevention of colorectal adenoma recurrence:: a randomised intervention trial [J].
Bonithon-Kopp, C ;
Kronborg, O ;
Giacosa, A ;
Räth, U ;
Faivre, J .
LANCET, 2000, 356 (9238) :1300-1306
[12]   Folate and alcohol intakes: Related or independent roles in the adenoma-carcinoma sequence? [J].
BoutronRuault, MC ;
Senesse, P ;
Faivre, J ;
Couillault, C ;
Belghiti, C .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 1996, 26 (03) :337-346
[13]  
Bruce WR, 2000, CANCER EPIDEM BIOMAR, V9, P1271
[14]   COLONIC FERMENTATION OF DIETARY FIBER TO SHORT CHAIN FATTY-ACIDS IN PATIENTS WITH ADENOMATOUS POLYPS AND COLONIC-CANCER [J].
CLAUSEN, MR ;
BONNEN, H ;
MORTENSEN, PB .
GUT, 1991, 32 (08) :923-928
[15]  
*COMA, 1998, REP WORK GROUP DIET
[16]  
Faivre J, 1997, EUR J CANCER PREV, V6, P127
[17]  
FAIVRE J, 1987, CAUSATION PREVENTION
[18]   FOLATE INTAKE AND CARCINOGENESIS OF THE COLON AND RECTUM [J].
FREUDENHEIM, JL ;
GRAHAM, S ;
MARSHALL, JR ;
HAUGHEY, BP ;
CHOLEWINSKI, S ;
WILKINSON, G .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1991, 20 (02) :368-374
[19]  
Gaard M, 1996, EUR J CANCER PREV, V5, P445
[20]   EPIDEMIOLOGY OF POLYPS IN THE RECTUM AND COLON - RECOVERY AND EVALUATION OF UNRESECTED POLYPS 2 YEARS AFTER DETECTION [J].
HOFF, G ;
FOERSTER, A ;
VATN, MH ;
SAUAR, J ;
LARSEN, S .
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 1986, 21 (07) :853-862