Methylphenidate enhances both intracortical inhibition and facilitation in healthy adults

被引：36

作者：

Kirschner, J

Moll, GH

Fietzek, UM

Heinrich, H

Mall, V

Berweck, S

Heinen, F

Rothenberger, A

机构：

[1] Univ Freiburg, Kinderklin, Dept Neuropediat & Muscle Disorders, Freiburg, Germany

[2] Univ Klinikum Gottingen, Dept Child & Adolescent Psychiat, Gottingen, Germany

[3] Christian Albrechts Univ Kiel Klinikum, Dept Neurol, Kiel, Germany

[4] Childrens Hosp, Wedau Kliniken, Duisburg, Germany

来源：

PHARMACOPSYCHIATRY | 2003年 / 36卷 / 02期

关键词：

HUMAN MOTOR CORTEX; DEFICIT HYPERACTIVITY DISORDER; EXCITABILITY; ATTENTION; PHARMACOKINETICS; NARCOLEPSY; MECHANISMS; MODULATION; RESPONSES; BRAIN;

D O I：

10.1055/s-2003-39049

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Transcranial magnetic stimulation was used to investigate the effect of the psychostimulant drug methylphenidate (MPH) on motor cortex excitability in healthy adults (n = 12) in a placebo-controlled, Crossover design study. MPH caused an enhancement of intracortical inhibition as well as intracortical facilitation. Enhancement of both of these TMS parameters was unexpected and suggests that MPH exerts its action on the motor cortex not only through the dopaminergic neurotransmitter system.

引用

页码：79 / 82

页数：4

共 16 条

[1] ALDRICH MS, 1994, SLEEP, V17, P598
[2] Behavioral inhibition, sustained attention, and executive functions: Constructing a unifying theory of ADHD
Barkley, RA
[J]. PSYCHOLOGICAL BULLETIN, 1997, 121 (01) : 65 - 94
[3] Mechanisms influencing stimulus-response properties of the human corticospinal system
Boroojerdi, B
Battaglia, F
Muellbacher, W
Cohen, LG
[J]. CLINICAL NEUROPHYSIOLOGY, 2001, 112 (05) : 931 - 937
[4] DIFFERENTIAL MODULATION BY DOPAMINE OF RESPONSES EVOKED BY EXCITATORY AMINO-ACIDS IN HUMAN CORTEX
CEPEDA, C
RADISAVLJEVIC, Z
PEACOCK, W
LEVINE, MS
BUCHWALD, NA
[J]. SYNAPSE, 1992, 11 (04) : 330 - 341
[5] PRIMATE MODELS OF MOVEMENT-DISORDERS OF BASAL GANGLIA ORIGIN
DELONG, MR
[J]. TRENDS IN NEUROSCIENCES, 1990, 13 (07) : 281 - 285
[6] Treatment modalities for narcolepsy
Fry, JM
[J]. NEUROLOGY, 1998, 50 (02) : S43 - S48
[7] Pharmacokinetics and clinical effectiveness of methylphenidate
Kimko, HC
Cross, JT
Abernethy, DR
[J]. CLINICAL PHARMACOKINETICS, 1999, 37 (06) : 457 - 470
[8] CORTICOCORTICAL INHIBITION IN HUMAN MOTOR CORTEX
KUJIRAI, T
CARAMIA, MD
ROTHWELL, JC
DAY, BL
THOMPSON, PD
FERBERT, A
WROE, S
ASSELMAN, P
MARSDEN, CD
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1993, 471 : 501 - 519
[9] Deficient intracortical inhibition in drug-naive children with attention-deficit hyperactivity disorder is enhanced by methylphenidate
Moll, GH
Heinrich, H
Trott, GE
Wirth, S
Rothenberger, A
[J]. NEUROSCIENCE LETTERS, 2000, 284 (1-2) : 121 - 125
[10] Noradrenergic modulation of human cortex excitability by the presynaptic α2-antagonist yohimbine
Plewnia, C
Bartels, M
Cohen, L
Gerloff, C
[J]. NEUROSCIENCE LETTERS, 2001, 307 (01) : 41 - 44

← 1 2 →