Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression

被引：53

作者：

Diniz, Breno Satler ^{[1
]}

Teixeira, Antonio Lucio ^{[2
,3
]}

Talib, Leda Leme ^{[1
]}

Mendonca, Vanessa Amaral ^{[2
,3
]}

Gattaz, Wagner Farid ^{[1
]}

Forlenza, Orestes Vicente ^{[1
]}

机构：

[1] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, Lab Neurosci LIM 27, BR-05403010 Sao Paulo, Brazil

[2] Univ Fed Minas Gerais, Inst Biol Sci, Lab Immunopharmacol, Grp Neuroimmunol, Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG, Brazil

来源：

WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY | 2010年 / 11卷 / 03期

基金：

巴西圣保罗研究基金会;

关键词：

Brain-derived neurotrophic factor; geriatric depression; late-onset depression; physiopathology; cognition; WHITE-MATTER HYPERINTENSITIES; FACTOR VAL66MET POLYMORPHISM; MILD COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE; MAJOR DEPRESSION; BDNF SERUM; DIAGNOSIS; DISORDER;

D O I：

10.3109/15622970903544620

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Objectives. The aim of the present study is to investigate serum BDNF levels in older depressed patients as compared to healthy elderly controls. Methods. Twenty-nine elderly subjects with major depression and 42 healthy older adults were enrolled to this study. All depressed patients were antidepressant-free for at least 1 month prior clinical and laboratorial assessments. Serum BDNF levels were determined by sandwich ELISA. Results. BDNF levels were lower in elderly depressed patients as compared to controls (P = 0.034). Patients with late-onset depression had the lowest BDNF level (median 478.5, interquartile range 373.5-740.9 pg/l) when compared to early-onset depression (median 620.7, interquartile range 366.1-971.9 pg/l) and healthy controls (median 711.3, interquartile range 534.7-1181.0 pg/l) (P < 0.03). Conclusions. Reduced serum BDNF level may be a state marker of late-life depression in non-medicated elderly patients. Our findings provide further evidences that reduced neurotrophic support may have an important role in the physiopathology of late-life depression.

引用

页码：550 / 555

页数：6

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[21] BDNF serum and CSF concentrations in Alzheimer's disease, normal pressure hydrocephalus and healthy controls [J].