Gonadotropin-releasing hormone agonist to induce final oocyte maturation prevents the development of ovarian hyperstimulation syndrome in high-risk patients and leads to improved clinical outcomes compared with coasting

被引：42

作者：

DiLuigi, Andrea J. ^{[1
]}

Engmann, Lawrence ^{[1
]}

Schmidt, David W. ^{[1
]}

Maier, Donald B. ^{[1
]}

Nulsen, John C. ^{[1
]}

Benadiva, Claudio A. ^{[1
]}

机构：

[1] Univ Connecticut Hlth Ctr, Ctr Adv Reprod Serv, Div Reprod Endocrinol & Infertil, Farmington, CT 06030 USA

来源：

FERTILITY AND STERILITY | 2010年 / 94卷 / 03期

关键词：

GnRH agonist; GnRH antagonist; OHSS; high responder; IN-VITRO FERTILIZATION; HUMAN CHORIONIC-GONADOTROPIN; GNRH ANTAGONIST GANIRELIX; EMBRYO-TRANSFER; FOLLICULAR MATURATION; INVITRO FERTILIZATION; SYNDROME OHSS; OVULATION; IVF; CYCLES;

D O I：

10.1016/j.fertnstert.2009.10.034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Ninety-four women undergoing IVF with peak E-2 level>4000 pg/mL received leuprolide acetate (LA) trigger (LA trigger group) or had gonadotropins withheld for one or more days (coasting group) followed by hCG trigger, unless cycle cancellation occurred. There were no cases of ovarian hyperstimulation syndrome in either group, and the LA trigger group had significantly more oocytes retrieved (26.9 +/- 9.5 vs. 17.7 +/- 9.3) P<0.001, more normally fertilized oocytes (15.0 +/- 7.8 vs. 10.3 +/- 6.3) P=0.01, and higher clinical and ongoing pregnancy rates than the coasting group (52.5% vs. 27.2%; 49.2% vs. 24.2%, P=0.02 for both comparisons, respectively). (Fertil Steril (R) 2010;94:1111-4. (C)2010 by American Society for Reproductive Medicine.)

引用

页码：1111 / 1114

页数：4

共 52 条

[21] Withholding gonadotropins ("coasting") to minimize the risk of ovarian hyperstimulation during superovulation and in vitro fertilization-embryo transfer cycles [J].