Usefulness of serum fibrinogen degradation product-E in sporadic cases of classical hemolytic uremic syndrome

被引：3

作者：

Aihara, Y ^{[1
]}

Nakamura, T ^{[1
]}

Unayama, T ^{[1
]}

Yoshida, Y ^{[1
]}

Yokota, S ^{[1
]}

机构：

[1] Yokohama City Univ, Med Ctr, Dept Pediat, Minami Ku, Yokohama, Kanagawa 2320024, Japan

来源：

PEDIATRICS INTERNATIONAL | 2000年 / 42卷 / 05期

关键词：

fibrin/fibrinogen degradation product-E fraction; hemolytic uremic syndrome; marker; Shiga toxin-producing Escherichia coli O15 : H7;

D O I：

10.1046/j.1442-200x.2000.01266.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Hemolytic uremic syndrome (HUS) associated with Shiga toxin (Stx)-producing Escherichia coli O157:H7 infection is one of the diseases causing acute renal failure in young children. Although HUS is still a serious disease in children, no reliable predictive markers for HUS nor markers of disease severity are available so far. Recently, we experienced a sporadic case of typical HUS caused by Stx-producing E. coli O157:H7 and detected, at the prodromal stage, a high level of serum fibrin/fibrinogen degradation product-E (FDP-E) fraction. Methods: To assess the usefulness of FDP-E for the treatment of HUS in clinical practice, we retrospectively examined serum levels of FDP-E in 22 patients with bloody diarrhea with or without HUS. Results: There were significantly increased levels of serum FDP-E in patients with HUS, but not in those without HUS. Furthermore, serum levels of FDP-E may correlate with disease severity in patients with HUS. Conclusions: These results suggest that serum levels of FDP-E may be a useful marker of HUS in clinical practice.

引用

页码：523 / 527

页数：5