Cell-mediated immunity and the outcome of hepatitis C virus infection

被引：155

作者：

Shoukry, NH ^{[1
]}

Cawthon, AG

Walker, CM

机构：

[1] Columbus Childrens Res Inst, Ctr Vaccine & Immun, Columbus, OH 43205 USA

[2] Ohio State Univ, Coll Med & Publ Hlth, Columbus, OH 43205 USA

来源：

ANNUAL REVIEW OF MICROBIOLOGY | 2004年 / 58卷

关键词：

liver disease; viral hepatitis; T lymphocytes; MHC; persistent infection;

D O I：

10.1146/annurev.micro.58.030603.123836

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The hepatitis C virus (HCV) infects approximately three percent of the world's population. Some individuals resolve the infection spontaneously, but the majority develop persistent viremia that often causes progressive liver disease. There is an emerging consensus that cellular immune responses are essential for spontaneous resolution of acute hepatitis C and long-term protection from persistent infection. This review focuses on the recent advances in understanding mechanisms of protective immunity and why they fail in most infected individuals. The distinct yet. complementary role of CD4+ and CD8+ T lymphocytes in this process is highlighted.

引用

页码：391 / 424

页数：34

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