The complexities of skeletal biology

被引:308
作者
Karsenty, G [1 ]
机构
[1] Baylor Coll Med, Bone Dis Program Texas, Houston, TX 77030 USA
关键词
D O I
10.1038/nature01654
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
For a long time, the skeleton was seen as an amorphous tissue of little biological interest. But such a view ignored the large number of genetic and degenerative diseases affecting this organ. Over the past 15 years, molecular and genetic studies have modified our understanding of skeletal biology. By so doing this progress has affected our understanding of diseases and suggested in many instances new therapeutic opportunities.
引用
收藏
页码:316 / 318
页数:3
相关论文
共 20 条
  • [1] The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: A 2-year open randomized controlled multicenter trial
    Bex, M
    Abs, R
    Maiter, D
    Beckers, A
    Lamberigts, G
    Bouillon, R
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2002, 17 (06) : 1081 - 1094
  • [2] Patterning mechanisms controlling vertebrate limb development
    Capdevila, J
    Belmonte, JCI
    [J]. ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, 2001, 17 : 87 - 132
  • [3] EXPERIMENTAL-ANALYSIS OF ORIGIN OF WING MUSCULATURE IN AVIAN EMBRYOS
    CHRIST, B
    JACOB, HJ
    JACOB, M
    [J]. ANATOMY AND EMBRYOLOGY, 1977, 150 (02): : 171 - 186
  • [4] Leptin inhibits bone formation through a hypothalamic relay: A central control of bone mass
    Ducy, P
    Amling, M
    Takeda, S
    Priemel, M
    Schilling, AF
    Beil, FT
    Shen, JH
    Vinson, C
    Rueger, JM
    Karsenty, G
    [J]. CELL, 2000, 100 (02) : 197 - 207
  • [5] A re-examination of proximodistal patterning during vertebrate limb development
    Dudley, AT
    Ros, MA
    Tabin, CJ
    [J]. NATURE, 2002, 418 (6897) : 539 - 544
  • [6] Requirement for NF-κB in osteoclast and B-cell development
    Franzoso, G
    Carlson, L
    Xing, LP
    Poljak, L
    Shores, EW
    Brown, KD
    Leonardi, A
    Tran, T
    Boyce, BF
    Siebenlist, U
    [J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3482 - 3496
  • [7] LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    Gong, YQ
    Slee, RB
    Fukai, N
    Rawadi, G
    Roman-Roman, S
    Reginato, AM
    Wang, HW
    Cundy, T
    Glorieux, FH
    Lev, D
    Zacharin, M
    Oexle, K
    Marcelino, J
    Suwairi, W
    Heeger, S
    Sabatakos, G
    Apte, S
    Adkins, WN
    Allgrove, J
    Arslan-Kirchner, M
    Batch, JA
    Beighton, P
    Black, GCM
    Boles, RG
    Boon, LM
    Borrone, C
    Brunner, HG
    Carle, GF
    Dallapiccola, B
    De Paepe, A
    Floege, B
    Halfhide, ML
    Hall, B
    Hennekam, RC
    Hirose, T
    Jans, A
    Jüppner, H
    Kim, CA
    Keppler-Noreuil, K
    Kohlschuetter, A
    LaCombe, D
    Lambert, M
    Lemyre, E
    Letteboer, T
    Peltonen, L
    Ramesar, RS
    Romanengo, M
    Somer, H
    Steichen-Gersdorf, E
    Steinmann, B
    [J]. CELL, 2001, 107 (04) : 513 - 523
  • [8] C-FOS - A KEY REGULATOR OF OSTEOCLAST-MACROPHAGE LINEAGE DETERMINATION AND BONE REMODELING
    GRIGORIADIS, AE
    WANG, ZQ
    CECCHINI, MG
    HOFSTETTER, W
    FELIX, R
    FLEISCH, HA
    WAGNER, EF
    [J]. SCIENCE, 1994, 266 (5184) : 443 - 448
  • [9] Osteopetrosis in mice lacking NF-kappa B1 and NF-kappa B2
    Iotsova, V
    Caamano, J
    Loy, J
    Yang, Y
    Lewin, A
    Bravo, R
    [J]. NATURE MEDICINE, 1997, 3 (11) : 1285 - 1289
  • [10] Reaching a genetic and molecular understanding of skeletal development
    Karsenty, G
    Wagner, EF
    [J]. DEVELOPMENTAL CELL, 2002, 2 (04) : 389 - 406