Tools for efficient high-throughput synthesis

被引：35

作者：

Chighine, Alessandra ^{[1
]}

Sechi, Gianluca ^{[1
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Combinatorial Ctr Excellence, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

DRUG DISCOVERY TODAY | 2007年 / 12卷 / 11-12期

关键词：

D O I：

10.1016/j.drudis.2007.04.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Here, we detail the major developments in methods and techniques that are applicable to high-throughput synthesis that have evolved over the past five years, with an emphasis on the combination of microwave-based synthesis with techniques such as polymer-assisted purification and immobilized reagents and catalysts. Other aspects, such as automation, miniaturization and flow-based synthesis, are also presented as approaches that can be used for the rapid discovery and optimization of small organic molecules.

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页码：459 / 464

页数：6

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