Cytochrome c is a hydrogen peroxide scavenger in mitochondria

被引：37

作者：

Wang, ZB ^{[1
]}

Li, M ^{[1
]}

Zhao, YG ^{[1
]}

Xu, JX ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Biophys, Ctr Mol Biol, Natl Lab Biomacromol, Beijing 100101, Peoples R China

来源：

PROTEIN AND PEPTIDE LETTERS | 2003年 / 10卷 / 03期

关键词：

cytochrome c; hydrogen peroxide; mitochondria; succinate-cytochrome c reductase;

D O I：

10.2174/0929866033479013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of succinate-cytochrome c reductase (SCR) reduced cytochrome c to scavenge H2O2 was investigated. H2O2, whether added or produced by SCR, was efficiently removed when cytochrome c was reduced by SCR. On the other hand, ferrocytochrome c underwent re-oxidization when H2O2 was added. Thus, these results indicate that cytochrome c reduced by succinate-cytochrome c reductase has the ability to regulate H2O2 in mitochondria.

引用

收藏

页码：247 / 253

页数：7

相关论文

共 19 条

[1]

ALLEN RC, 1986, METHOD ENZYMOL, V133, P449

[2] Glutamate neurotoxicity, oxidative stress and mitochondria [J].

Atlante, A ;

Calissano, P ;

Bobba, A ;

Giannattasio, S ;

Marra, E ;

Passarella, S .

FEBS LETTERS, 2001, 497 (01) :1-5

[3] Mitochondrial oxygen radical generation and leak: Sites of production in state 4 and 3, organ specificity, and relation to aging and longevity [J].

Barja, G .

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1999, 31 (04) :347-366

[4] EFFECT OF DIETARY DEFICIENCY AND SUPPLEMENTATION WITH ALL-RAC-ALPHA-TOCOPHEROL ON HEPATIC CONTENT IN RATS [J].

BJORNEBOE, A ;

NENSETER, MS ;

HAGEN, BF ;

BJORNEBOE, GEA ;

PRYDZ, K ;

DREVON, CA .

JOURNAL OF NUTRITION, 1991, 121 (08) :1208-1213

[5] HYDROPEROXIDE METABOLISM IN MAMMALIAN ORGANS [J].

CHANCE, B ;

SIES, H ;

BOVERIS, A .

PHYSIOLOGICAL REVIEWS, 1979, 59 (03) :527-605

[6] On the virtual existence of superoxide anions in mitochondria: Thoughts regarding its role in pathophysiology [J].

Forman, HJ ;

Azzi, A .

FASEB JOURNAL, 1997, 11 (05) :374-375

[7] Superoxide anion radical (O-2 radical anion), superoxide dismutases, and related matters [J].

Fridovich, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (30) :18515-18517

[8] Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c [J].

Liu, XS ;

Kim, CN ;

Yang, J ;

Jemmerson, R ;

Wang, XD .

CELL, 1996, 86 (01) :147-157

[9]

Margoliash E., 1967, Methods Enzymol, V10, P339, DOI [DOI 10.1016/0076-6879(67)10064-5, 10.1016/0076-6879(67)10064-5]

[10] Reactive oxygen species, mitochondria, apoptosis and aging [J].

Papa, S ;

Skulachev, VP .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 1997, 174 (1-2) :305-319