Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA

被引：111

作者：

Krieg, AM ^{[1
]}

Wagner, H

机构：

[1] Dept Vet Affairs Med Ctr, Iowa City, IA 52246 USA

[2] Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[3] Coley Pharmaceut Grp, Wellesley, MA 02481 USA

[4] Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-5699(00)01719-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The vertebrate immune system recognizes bacterial DNA ns foreign based on its content of unmethylated CpG motifs. The detection of CpG motifs by the innate immune system induces immune responses that are strongly Th1-biased. These responses can be mimicked using synthetic oligonucleotides, which have shown significant effects as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic conditions ill model systems.

引用

页码：521 / 526

页数：6

共 68 条

[1] Chlamydia infections and heart disease linked through antigenic mimicry
Bachmaier, K
Neu, N
de la Maza, LM
Pal, S
Hessel, A
Penninger, JM
[J]. SCIENCE, 1999, 283 (5406) : 1335 - 1339
[2] Ballas ZK, 1996, J IMMUNOL, V157, P1840
[3] Dendritic cells and the control of immunity
Banchereau, J
Steinman, RM
[J]. NATURE, 1998, 392 (6673) : 245 - 252
[4] Non-coding plasmid DNA induces IFN-γ in vivo and suppresses autoimmune encephalomyelitis
Boccaccio, GL
Mor, F
Steinman, L
[J]. INTERNATIONAL IMMUNOLOGY, 1999, 11 (02) : 289 - 296
[5] Bohle B, 1999, EUR J IMMUNOL, V29, P2344, DOI 10.1002/(SICI)1521-4141(199907)29:07<2344::AID-IMMU2344>3.0.CO
[6] 2-R
[7] Broide D, 1998, J IMMUNOL, V161, P7054
[8] Carpentier AF, 1999, CANCER RES, V59, P5429
[9] CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
Chu, RS
Targoni, OS
Krieg, AM
Lehmann, PV
Harding, CV
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (10) : 1623 - 1631
[10] Cowdery JS, 1999, J IMMUNOL, V162, P6770

← 1 2 3 4 5 6 7 →