LET-413 is a basolateral protein required for the assembly of adherens junctions in Caenorhabditis elegans

被引：145

作者：

Legouis, R

Gansmuller, A

Sookhareea, S

Bosher, JM

Baillie, DL

Labouesse, M

机构：

[1] ULP, INSERM, CNRS, Inst Genet & Biol Mol & Cellulaire, F-67404 Illkirch Graffenstaden, France

[2] Simon Fraser Univ, Dept Biol Sci, Inst Mol Biol & Biochem, Burnaby, BC V5A 1S6, Canada

来源：

NATURE CELL BIOLOGY | 2000年 / 2卷 / 07期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1038/35017046

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epithelial cells are polarized, with apical and basal compartments demarcated by tight and adherens junctions. Proper establishment of these subapical junctions is critical for normal development and histogenesis, We report the characterization of the gene let-413 which has a critical role in assembling adherens junctions in Caenorhabditis elegans, In let-413 mutants, adherens junctions are abnormal and mislocalized to more basolateral positions, epithelial cell polarity is affected and the actin cytoskeleton is disorganized. The LET-413 protein contains one PDZ domain and 16 leucine-rich repeats with high homology to proteins known to interact with small GTPases, Strikingly, LET-413 localizes to the basolateral membrane. We suggest that LET-413 acts as an adaptor protein involved in polarizing protein trafficking in epithelial cells.

引用

页码：415 / 422

页数：8

共 51 条

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