Mass transport effect of mesoscopic domains in the amperometric response of an electroactive species: Modeling for its applications in biomolecule detection

被引：5

作者：

Gonzalez, Graciela ^{[1
]}

Priano, Graciela ^{[1
]}

Guenther, Mauricio ^{[1
]}

Battaglini, Fernando ^{[1
]}

机构：

[1] Univ Buenos Aires, INQUIMAE DQIAQF, Fac Ciencias Exactas & Nat, RA-1428 Buenos Aires, DF, Argentina

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2010年 / 144卷 / 02期

关键词：

Mesoporous membrane; Digital simulation; Amperometry; Label-free sensing; POROUS SILICON; ELECTRODES; MEMBRANES;

D O I：

10.1016/j.snb.2008.11.006

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

We report the numerical Simulation of an electrochemical system compromising a mesoporous material placed at a close distance of a working electrode. The effect of mesoscopic domains to the amperometric response of an electroactive species by applying a cyclic voltammetry is Simulated to establish the influence of different parameters on the sensitivity of this system to detect molecules able to block the pores. Alumina membranes were chosen as mesoporous material; they were modified with anti-horseradish peroxidase as model system to test the behavior predicted by the simulation. The label-free assembled electrochemical system shows a reproducible behavior and it is able to detect a 10 nM protein concentration. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：349 / 353

页数：5

共 21 条

[1]

ANDERSON RC, 1990, SENSOR ACTUAT A-PHYS, V23, P835

[2]

Bard A.J., 2001, ELECTROCHEMICAL METH, V2nd, P236

[3] Resistive-pulse sensing - From microbes to molecules [J].