Apolipoprotein E polymorphism and atherosclerosis

被引:49
作者
Kolovou, G
Daskalova, D
Mikhailidis, DP
机构
[1] Onassis Cardiac Surg Ctr, Dept Cardiol, Athens 17674, Greece
[2] UCL Royal Free & Univ Coll, Royal Free Hosp, Sch Med, Dept Clin Biochem,Vasc Dis Prevent Clin, London, England
关键词
D O I
10.1177/000331970305400108
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
The relationship between apolipoprotein (apo) E and vascular disease has been the subject of a considerable amount of research. However, this relationship is far from clearly defined. This deficiency appears to be due to a multitude of factors. Among these are differences in ethnicity, age (and possibly gender), diagnostic criteria, and environmental factors (eg, diet and smoking) that have contributed to the contradictory findings. Several diseases and their treatment may also influence this relationship. There are also documented interactions between apo E genotypes and other genes or vascular risk factors. One possible clinically relevant application of identifying the apo E genotype could be to assess the response to a particular drug treatment. It may also be that apo E polymorphism will become a good predictor of vascular death (eg, from myocardial infarction or stroke) rather than an indicator of the risk of developing vascular disease but without an acute ischemic event. More research is required to define the place of apo E genotyping in the management of vascular disease in its various forms. Whatever the future brings, the evaluation of apo E genotypes will need to be rapid, cheap, and technically undemanding before this investigation becomes widely available and clinically relevant.
引用
收藏
页码:59 / 71
页数:13
相关论文
共 155 条
[1]   The apolipoprotein E4 allele is not associated with an abnormal lipid profile in a Native American population following its traditional lifestyle [J].
Aguilar, CA ;
Talavera, G ;
Ordovas, JM ;
Barriguete, JA ;
Guillén, LE ;
Leco, ME ;
Pedro-Botet, J ;
Gonzalez-Barranco, J ;
Gómez-Pérez, FJ ;
Rull, JA .
ATHEROSCLEROSIS, 1999, 142 (02) :409-414
[2]   Treatment with atorvastatin to the National Cholesterol Educational Program goal versus 'usual' care in secondary coronary heart disease prevention - The GREek Atorvastatin and Coronary-heart-disease Evaluation (GREACE) Study [J].
Athyros, VG ;
Papageorgiou, AA ;
Mercouris, BR ;
Athyrou, VV ;
Symeonidis, AN ;
Basayannis, EO ;
Demitriadis, DS ;
Kontopoulos, AG .
CURRENT MEDICAL RESEARCH AND OPINION, 2002, 18 (04) :220-228
[3]   Effects of apolipoprotein E genotypes and other risk factors on the development of coronary artery disease in Southern Turkey [J].
Attila, G ;
Acartürk, E ;
Eskandari, G ;
Akpinar, O ;
Tuli, A ;
Kanadasi, M ;
Kayrin, L .
CLINICA CHIMICA ACTA, 2001, 312 (1-2) :191-196
[4]   DIRECT PHENOTYPING OF HUMAN APOLIPOPROTEIN-E IN PLASMA - APPLICATION TO POPULATION FREQUENCY-DISTRIBUTION IN PARIS (FRANCE) [J].
BAILLEUL, S ;
COUDERC, R ;
LANDAIS, V ;
LEFEVRE, G ;
RAICHVARG, D ;
ETIENNE, J .
HUMAN HEREDITY, 1993, 43 (03) :159-165
[5]   Apolipoprotein E genotypes and response of plasma lipids and progression-regression of coronary atherosclerosis to lipid-lowering drug therapy [J].
Ballantyne, CM ;
Herd, JA ;
Stein, EA ;
Ferlic, LL ;
Dunn, JK ;
Gotto, AM ;
Marian, AJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (05) :1572-1578
[6]  
Batalla A, 2000, CLIN CHEM, V46, P1910
[7]   Physical activity may modulate effects of ApoE genotype on lipid profile [J].
Bernstein, MS ;
Costanza, MC ;
James, RW ;
Morris, MA ;
Cambien, F ;
Raoux, S ;
Morabia, A .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (01) :133-140
[8]   Statins and blood pressure regulation [J].
Borghi C. ;
Veronesi M. ;
Prandin M.G. ;
Dormi A. ;
Ambrosioni E. .
Current Hypertension Reports, 2001, 3 (4) :281-288
[9]   Apolipoprotein E phenotype and the efficacy of intravenous tissue plasminogen activator in acute ischemic stroke [J].
Broderick, J ;
Lu, M ;
Jackson, C ;
Pancioli, A ;
Tilley, BC ;
Fagan, SC ;
Kothari, R ;
Levine, SR ;
Marler, JR ;
Lyden, PD ;
Haley, EC ;
Brott, T ;
Grotta, JC .
ANNALS OF NEUROLOGY, 2001, 49 (06) :736-744
[10]   Acute myocardial infarction in young adults: Prognostic role of angiotensin-converting enzyme, angiotensin II type I receptor, apolipoprotein E, endothelial constitutive nitric oxide synthase, and glycoprotein IIIa genetic polymorphisms at medium-term follow-up [J].
Brscic, E ;
Bergerone, S ;
Gagnor, A ;
Colajanni, E ;
Matullo, G ;
Scaglione, L ;
Cassader, M ;
Gaschino, G ;
Di Leo, M ;
Brusca, A ;
Pagano, GF ;
Piazza, A ;
Trevi, GP .
AMERICAN HEART JOURNAL, 2000, 139 (06) :979-984