Design and synthesis of photochemically controllable caspase-3

被引：35

作者：

Endo, M ^{[1
]}

Nakayama, K ^{[1
]}

Kaida, Y ^{[1
]}

Majima, T ^{[1
]}

机构：

[1] Osaka Univ, Inst Sci & Ind Res, Ibaraki, Osaka 5670047, Japan

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2004年 / 43卷 / 42期

关键词：

apoptosis; bioorganic chemistry; enzymes; photochemistry; photolysis;

D O I：

10.1002/anie.200460889

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The selective cleavage achieved by activated caspase-8 has been mimicked by using a photofunctionalized caspase-3 having 2-nitrophenylglycine (Npg) at a specific position of the peptide chain (see picture). The study shows that the activity of caspase-3 has been clearly expressed by photoirradiation and that autocleavage of caspase-3 has been suppressed by the site-selective incorporation of the Npg residue.

引用

页码：5643 / 5645

页数：3