TorsinA accumulation in Lewy bodies in sporadic Parkinson's disease

被引：80

作者：

Shashidharan, P

Good, PF

Hsu, A

Perl, DP

Brin, MF

Olanow, CW

机构：

[1] Mt Sinai Sch Med, Dept Neurol, New York, NY 10029 USA

[2] Mt Sinai Sch Med, Dept Pathol, New York, NY 10029 USA

来源：

BRAIN RESEARCH | 2000年 / 877卷 / 02期

关键词：

torsion dystonia; Lewy bodies; Parkinson's disease; alpha-synuclein;

D O I：

10.1016/S0006-8993(00)02702-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Parkinson's disease (PD) is a neurodegnerative disorder that is pathologically characterized by the presence of Lewy bodies in the brain. We show that Lewy bodies in PD are strongly immunoreactive for torsinA, the protein product of the DYT1 gene, which is associated with primary generalized dystonia. In the substantia nigra, torsinA immunoreactivity is localized to the periphery of Lewy bodies, whereas, in cortical Lewy bodies it is uniformly distributed. The significance of this finding is unknown, but may implicate torsinA in neuronal dysfunction that occurs in PD as well as in primary dystonia. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：379 / 381

页数：3

共 21 条

[1]

Alam ZI, 1997, J NEUROCHEM, V69, P1326

[2] Lewy body dementia [J].

Byrne, J .

JOURNAL OF THE ROYAL SOCIETY OF MEDICINE, 1997, 90 :14-15

[3]

FORNO LS, 1982, MOVEMENT DISORD, P25

[4]

Gai WP, 1996, ACTA NEUROPATHOL, V91, P78

[5] NEUROPATHOLOGY OF THE SUBSTANTIA-NIGRA [J].

GIBB, WRG .

EUROPEAN NEUROLOGY, 1991, 31 :48-59

[6] Protein nitration in Parkinson's disease [J].

Good, PF ;

Hsu, A ;

Werner, P ;

Perl, DP ;

Olanow, CW .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 1998, 57 (04) :338-342

[7]

JENNER P, 1996, NEUROLOGY S3, V47, P161

[8]

JENSEN PH, 2000, J BIOL CHEM

[9] MEIGE SYNDROME IN THE SPECTRUM OF LEWY BODY DISEASE [J].

MARK, MH ;

SAGE, JI ;

DICKSON, DW ;

HEIKKILA, RE ;

MANZINO, L ;

SCHWARZ, KO ;

DUVOISIN, RC .

NEUROLOGY, 1994, 44 (08) :1432-1436

[10]

Narhi L, 1999, J BIOL CHEM, V274, P13728

← 1 2 3 →