Studies on the synthesis and antibacterial activities of polymeric quaternary ammonium salts from dimethylaminoethyl methacrylate

被引：316

作者：

Lu, Guiqian ^{[1
]}

Wu, Dingcai ^{[1
]}

Fu, Ruowen ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Chem & Chem Engn, PCFM Lab, Inst Mat Sci, Guangzhou 510275, Peoples R China

来源：

REACTIVE & FUNCTIONAL POLYMERS | 2007年 / 67卷 / 04期

基金：

高等学校博士学科点专项科研基金; 中国国家自然科学基金;

关键词：

azo polymer; polymeric quaternary ammonium salts; biopolymer; antibacterial activity;

D O I：

10.1016/j.reactfunctpolym.2007.01.008

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Four quaternary ammonium salt monomers were synthesized from dimethylaminoethyl methacrylate (DMAEMA) by quaternization with benzyl] chloride (BC), butyl bromide (BB), dodecyl bromide (DB) or hexadecyl bromide (HB), respectively. And then, the monomers were homopolymerized to obtain four polymeric quaternary ammonium materials with different lengths of alkyl chain, which were referred to as poly(DMAEMA-BC), poly(DMAEMA-BB), poly(DMAEMA-BB) and poly(DMAEMA-HB), respectively. The resultant monomers and related polymers were characterized by elemental analysis, FTIR, NMR, thermogravimetric analysis (TGA) and so on. Their bactericidal activities were evaluated by determining minimum bactericidal concentration (MBC) values and inhibitory zone diameters against Grampositive bacteria (S. aureus) and Gram-negative bacteria (E. coli), respectively. The results showed that the MBC values of monomer DMAEMA-DB and DMAEMA-HB were 12-24 mu g/mL against E. coli and S. aureus. However, the MBC values of monomer DMAEMA-BC and DMAEMA-BB were higher than 50 mg/mL against test microbe. It was very interesting that poly(DMAEMA-BC) and poly(DMAEMA-BB) exhibited greater bactericidal activities than their precursory monomers, but poly(DMAEMA-DB) and poly(DMAEMA-HB) present contrary results. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：355 / 366

页数：12

共 39 条

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