New adjuvants for human vaccines

被引：303

作者：

Mbow, M. Lamine ^{[2
]}

De Gregorio, Ennio ^{[1
]}

Valiante, Nicholas M. ^{[2
]}

Rappuoli, Rino ^{[1
]}

机构：

[1] Novartis Vaccines & Diagnost, Siena, Italy

[2] Novartis Vaccines & Diagnost, Cambridge, MA USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 03期

关键词：

T-CELL RESPONSES; DENDRITIC CELLS; ALUMINUM-HYDROXIDE; MF59-ADJUVANTED VACCINE; IMMUNOLOGICAL MEMORY; NALP3; INFLAMMASOME; IMMUNE-RESPONSES; INNATE IMMUNITY; IMMUNOGENICITY; EFFICACY;

D O I：

10.1016/j.coi.2010.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite their obvious benefits, decades of research and hundreds of pre-clinical candidates, only a handful of adjuvants are approved for prophylactic vaccination of humans. The slow pace of development is due to a number of knowledge gaps, the most important of which is the complexity involved in designing adjuvants that are both potent and well tolerated. Recent advances in our understanding of innate immunity have led to the identification of immune pathways and adjuvant formulations more suitable for clinical advancement. One area of particular interest is the discovery of agonists that target the toll-like receptors. This review highlights recent progress of clinically approved vaccine adjuvants and identifies potential novel adjuvants that can broaden the development of new vaccines against infectious diseases.

引用

页码：411 / 416

页数：6

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