New adjuvants for human vaccines

被引：303

作者：

Mbow, M. Lamine ^{[2
]}

De Gregorio, Ennio ^{[1
]}

Valiante, Nicholas M. ^{[2
]}

Rappuoli, Rino ^{[1
]}

机构：

[1] Novartis Vaccines & Diagnost, Siena, Italy

[2] Novartis Vaccines & Diagnost, Cambridge, MA USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 03期

关键词：

T-CELL RESPONSES; DENDRITIC CELLS; ALUMINUM-HYDROXIDE; MF59-ADJUVANTED VACCINE; IMMUNOLOGICAL MEMORY; NALP3; INFLAMMASOME; IMMUNE-RESPONSES; INNATE IMMUNITY; IMMUNOGENICITY; EFFICACY;

D O I：

10.1016/j.coi.2010.04.004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite their obvious benefits, decades of research and hundreds of pre-clinical candidates, only a handful of adjuvants are approved for prophylactic vaccination of humans. The slow pace of development is due to a number of knowledge gaps, the most important of which is the complexity involved in designing adjuvants that are both potent and well tolerated. Recent advances in our understanding of innate immunity have led to the identification of immune pathways and adjuvant formulations more suitable for clinical advancement. One area of particular interest is the discovery of agonists that target the toll-like receptors. This review highlights recent progress of clinically approved vaccine adjuvants and identifies potential novel adjuvants that can broaden the development of new vaccines against infectious diseases.

引用

收藏

页码：411 / 416

页数：6

相关论文

共 54 条

[11] Dendritic cells internalize vaccine adjuvant after intramuscular injection [J].

Dupuis, M ;

Murphy, TJ ;

Higgins, D ;

Ugozzoli, M ;

van Nest, G ;

Ott, G ;

McDonald, DM .

CELLULAR IMMUNOLOGY, 1998, 186 (01) :18-27

[12] Comparison of the immunogenicity and safety of Cervarix™ and Gardasil® human papillomavirus (HPV) cervical cancer vaccines in healthy women aged 18-45 years [J].

Einstein, Mark H. ;

Baron, Mira ;

Levin, Myron J. ;

Chatterjee, Archana ;

Edwards, Robert P. ;

Zepp, Fred ;

Carletti, Isabelle ;

Dessy, Francis J. ;

Trofa, Andrew F. ;

Schuind, Anne ;

Dubin, Gary .

HUMAN VACCINES, 2009, 5 (10) :705-719

[13] Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants [J].

Eisenbarth, Stephanie C. ;

Colegio, Oscar R. ;

O'Connor, William, Jr. ;

Sutterwala, Fayyaz S. ;

Flavell, Richard A. .

NATURE, 2008, 453 (7198) :1122-U13

[14] The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity [J].

Franchi, Luigi ;

Nunez, Gabriel .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (08) :2085-2089

[15] Fast rise of broadly cross-reactive antibodies after boosting long-lived human memory B cells primed by an MF59 adjuvanted prepandemic vaccine [J].

Galli, Grazia ;

Hancock, Kathy ;

Hoschler, Katja ;

DeVos, Joshua ;

Praus, Michaela ;

Bardelli, Monia ;

Malzone, Carmine ;

Castellino, Flora ;

Gentile, Chiara ;

McNally, Teresa ;

Del Giudice, Giuseppe ;

Banzhoff, Angelika ;

Brauer, Volker ;

Montomoli, Emanuele ;

Zambon, Maria ;

Katz, Jacqueline ;

Nicholson, Karl ;

Stephenson, Iain .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (19) :7962-7967

[16] Adjuvanted H5N1 vaccine induces early CD4+ T cell response that predicts long-term persistence of protective antibody levels [J].

Galli, Grazia ;

Medini, Duccio ;

Borgogni, Erica ;

Zedda, Luisanna ;

Bardelli, Monia ;

Malzone, Carmine ;

Nuti, Sandra ;

Tavarini, Simona ;

Sammicheli, Chiara ;

Hilbert, Anne K. ;

Brauer, Volker ;

Banzhoff, Angelika ;

Rappuoli, Rino ;

Del Giudice, Giuseppe ;

Castellino, Flora .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (10) :3877-3882

[17] Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04) compared to aluminium salt only [J].

Giannini, Sandra L. ;

Hanon, Emmanuel ;

Moris, Philippe ;

Van Mechelen, Marcelle ;

Morel, Sandra ;

Dessy, Francis ;

Fourneau, Marc A. ;

Colau, Brigitte ;

Suzich, Joann ;

Losonksy, Genevieve ;

Martin, Marie-Therese ;

Dubin, Gary ;

Wettendorff, Martine A. .

VACCINE, 2006, 24 (33-34) :5937-5949

[18] HISTOPATHOLOGICAL STUDIES OF REACTIONS IN MICE INJECTED WITH ALUMINUM-ADSORBED TETANUS TOXOID [J].

GOTO, N ;

AKAMA, K .

MICROBIOLOGY AND IMMUNOLOGY, 1982, 26 (12) :1121-1132

[19] Local tissue irritating effects and adjuvant activities of calcium phosphate and aluminium hydroxide with different physical properties [J].

Goto, N ;

Kato, H ;

Maeyama, J ;

Shibano, M ;

Saito, T ;

Yamaguchi, J ;

Yoshihara, S .

VACCINE, 1997, 15 (12-13) :1364-1371

[20] Currently approved prophylactic HPV vaccines [J].

Harper, Diane M. .

EXPERT REVIEW OF VACCINES, 2009, 8 (12) :1663-1679

← 1 2 3 4 5 6 →