Nutrient sensing and metabolic decisions

被引：117

作者：

Lindsley, JE ^{[1
]}

Rutter, J ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Dept Biochem, Salt Lake City, UT 84132 USA

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 2004年 / 139卷 / 04期

关键词：

AMPK; AMP kinase; hexosamine; O-GlcNAC; mTOR; PASK; PAS kinase; Sir2;

D O I：

10.1016/j.cbpc.2004.06.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cells have several sensory systems that detect energy and metabolic status and adjust flux through metabolic pathways accordingly. Many of these sensors and signaling pathways are conserved frorn yeast to mammals. In this review, we bring together information about five different nutrient-sensing pathways (AMP kinase, rnTOR, PAS kinase, hexosamine biosynthesis and Sir2), highlighting their similarities, differences and roles in disease. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：543 / 559

页数：17

共 200 条

[21]

CARLSON CA, 1973, J BIOL CHEM, V248, P378

[22] A YEAST GENE THAT IS ESSENTIAL FOR RELEASE FROM GLUCOSE REPRESSION ENCODES A PROTEIN-KINASE [J].

CELENZA, JL ;

CARLSON, M .

SCIENCE, 1986, 233 (4769) :1175-1180

[23] Effects of overexpression of glutamine:fructose-6-phosphate amidotransferase (GFAT) and glucosamine treatment on translocation of GLUT4 in rat adipose cells [J].

Chen, MG ;

Ing, BL ;

Robinson, KA ;

Feagin, AC ;

Buse, MG ;

Quon, MJ .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1997, 135 (01) :67-77

[24] Characterization of AMP-activated protein kinase γ-subunit isoforms and their role in AMP binding [J].

Cheung, PCF ;

Salt, IP ;

Davies, SP ;

Hardie, DG ;

Carling, D .

BIOCHEMICAL JOURNAL, 2000, 346 :659-669

[25]

CHOI JP, 1996, EUROPEAN J POLITICAL, V12, P273, DOI DOI 10.1016/0176-2680(95)00017-8

[26] RAPAMYCIN FKBP SPECIFICALLY BLOCKS GROWTH-DEPENDENT ACTIVATION OF AND SIGNALING BY THE 70 KD S6 PROTEIN-KINASES [J].

CHUNG, J ;

KUO, CJ ;

CRABTREE, GR ;

BLENIS, J .

CELL, 1992, 69 (07) :1227-1236

[27] Glucosamine regulation of glucose metabolism in cultured human skeletal muscle cells: Divergent effects on glucose transport/phosphorylation and glycogen synthase in non-diabetic and type 2 diabetic subjects [J].

Ciaraldi, TP ;

Carter, L ;

Nikoulina, S ;

Mudaliar, S ;

McClain, DA ;

Henry, RR .

ENDOCRINOLOGY, 1999, 140 (09) :3971-3980

[28] A nutrient sensor mechanism controls Drosophila growth [J].

Colombani, J ;

Raisin, S ;

Pantalacci, S ;

Radimerski, T ;

Montagne, J ;

Léopold, P .

CELL, 2003, 114 (06) :739-749

[29] O-glycosylation of nuclear and cytosolic proteins -: Dynamic interplay between O-GlcNAc and O-phosphate [J].

Comer, FI ;

Hart, GW .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (38) :29179-29182

[30] ROLE OF THE AMP-ACTIVATED PROTEIN-KINASE IN THE CELLULAR STRESS-RESPONSE [J].

CORTON, JM ;

GILLESPIE, JG ;

HARDIE, DG .

CURRENT BIOLOGY, 1994, 4 (04) :315-324

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