One-pot N-alkylation/Heck approach to substituted indoles

被引:17
作者
Weinrich, Melissa L. [1 ]
Beck, Hilary P. [1 ]
机构
[1] Amgen Inc, Chem Res & Discovery, San Francisco, CA 94080 USA
关键词
HALOGENATED NITROGEN; MODULAR SYNTHESIS; HECK CYCLIZATION; FUNCTIONALIZATION; HETEROCYCLES; CASCADE; HALOANILINES; ANNULATION; LIGANDS; OXYGEN;
D O I
10.1016/j.tetlet.2009.09.144
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Here, we report the palladium-catalyzed one-pot N-alkylation/Heck cyclization of anilines to substituted indoles employing Pd(OAc)(2)/XPhos. The scope and limitations of this methodology will be described. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码:6968 / 6972
页数:5
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