One-pot N-alkylation/Heck approach to substituted indoles

被引：17

作者：

Weinrich, Melissa L. ^{[1
]}

Beck, Hilary P. ^{[1
]}

机构：

[1] Amgen Inc, Chem Res & Discovery, San Francisco, CA 94080 USA

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 50期

关键词：

HALOGENATED NITROGEN; MODULAR SYNTHESIS; HECK CYCLIZATION; FUNCTIONALIZATION; HETEROCYCLES; CASCADE; HALOANILINES; ANNULATION; LIGANDS; OXYGEN;

D O I：

10.1016/j.tetlet.2009.09.144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here, we report the palladium-catalyzed one-pot N-alkylation/Heck cyclization of anilines to substituted indoles employing Pd(OAc)(2)/XPhos. The scope and limitations of this methodology will be described. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：6968 / 6972

页数：5

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