Establishment and characterization of a canine T-lymphoblastoid cell line derived from malignant lymphoma

被引：69

作者：

Momoi, Y ^{[1
]}

Okai, Y ^{[1
]}

Watari, T ^{[1
]}

Goitsuka, R ^{[1
]}

Tsujimoto, H ^{[1
]}

Hasegawa, A ^{[1
]}

机构：

[1] Univ Tokyo, Fac Agr, Dept Vet Internal Med, Bunkyo Ku, Tokyo 113, Japan

来源：

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY | 1997年 / 59卷 / 1-2期

关键词：

dog; lymphoma; T-cell line;

D O I：

10.1016/S0165-2427(97)00053-6

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A canine lymphoma cell line (CL-1) was established in culture from tumor cells found in the pleural fluid of a 7-year old female Japanese terrier with thymic form lymphoma. The CL-1 cells were positive for CD45 and MHC class II and negative for CD4, CD5, CD8, Thy-1 and B-cell specific antigen and surface immunoglobulin. The CL-1 cells had a rearranged T-cell receptor beta-chain gene and a germ-line form immunoglobulin gene, indicating that the CL-1 cells represented a monoclonally expanded population of canine alpha beta T-cell lineage. (C) 1997 Elsevier Science B.V.

引用

页码：11 / 20

页数：10