γ4-aminoxy peptides as new peptidomimetic foldamers

被引：23

作者：

Chen, F

Zhu, NY

Yang, D

机构：

[1] Univ Hong Kong, Dept Chem, Pokfulam, Hong Kong, Peoples R China

[2] Fudan Univ, Dept Chem, Shanghai 200433, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 49期

关键词：

D O I：

10.1021/ja044493+

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conformational properties of peptides 1-3 of γ-aminoxy acids have been investigated by using FT-IR, NMR spectroscopy, and X-ray crystallography. Diamide 1 consisting of unsubstituted γ-aminoxy acid cannot form intramolecular hydrogen bond. A novel γ N-O turn involving a 10-membered-ring intramolecular hydrogen bond between NHi+2 and COi is formed in γ4-aminoxy peptides 2 and 3. Triamides 3 prefers a new helical structure featuring two consecutive γ N-O turns. Therefore, γ4-aminoxy peptides represent new peptidomimetic foldamers. Copyright © 2004 American Chemical Society.

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页码：15980 / 15981

页数：2

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