RTX toxin actin cross-linking activity in clinical and environmental isolates of Vibrio cholerae

被引：18

作者：

Cordero, Christina L.

Sozhamannan, Shanmuga

Satchell, Karla J. Fullner

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Microbiol Immunol, Chicago, IL 60611 USA

[2] Naval Med Res Ctr, Bio Def Res Directorate, Silver Spring, MD 20852 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2007年 / 45卷 / 07期

关键词：

D O I：

10.1128/JCM.00349-07

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Vibrio cholerae strains from diverse O-antigen groups were evaluated for RTX toxin actin cross-linking activity. This study demonstrates that the actin cross-linking domain sequence is present within rtxA in the majority of clinical and environmental isolates tested, and the RTX toxin produced by these strains catalyzes the covalent cross-linking of cellular actin.

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收藏

页码：2289 / 2292

页数：4

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