The role of integrins in tumor angiogenesis

被引：88

作者：

Hwang, R

Varner, J

机构：

[1] Univ Calif San Diego, Dept Med, Moores Comprehens Canc Ctr, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Surg, Moores Comprehens Canc Ctr, La Jolla, CA 92093 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2004年 / 18卷 / 05期

关键词：

D O I：

10.1016/j.hoc.2004.09.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.

引用

页码：991 / +

页数：17

共 79 条

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2-I

[52] Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors [J].